If you've been stressed out and ignoring it—isn't everyone stressed right now?— it could be time to do something about it. That's because even though you may be basically healthy, tension is doing its stealthy damage. The latest evidence? Researchers have just linked high levels of the stress hormone cortisol to brain shrinkage and impaired memory in healthy middle-aged adults. And get this: The effect was more pronounced in women than in men.

This new research underscores an important point. Though stress affects your whole body, ground zero is your brain. It's not just the effects of cortisol—it's that teeth-grinders like traffic jams, personal snubs, and financial worries are perceived and interpreted by your gray matter. Fortunately, research focused on the brain is pointing to new, more effective ways to reduce your tension.

But first, let's drill down and see how and why your brain's natural reactions make you more vulnerable to the zings and arrows of tension.

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