| Symptoms of multiple myeloma | | Signs and symptoms of multiple myeloma can vary and, early in the disease, there may be none. When signs and symptoms do occur, they can include: | Bone pain, especially in your spine or chest Nausea Constipation Loss of appetite Mental fogginess or confusion Fatigue Frequent infections Weight loss Weakness or numbness in your legs Excessive thirst When to see a doctor Make an appointment with your doctor if you have any persistent signs and symptoms that worry you.
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