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Scientist uncovers clues to aging in mitochondria Posted: 18 May 2022 04:42 PM PDT Many age-related diseases share a common feature: the mitochondria of cells begin to malfunction. While the cause is not known, scientists have discovered a new mechanism of how mitochondria start to go wrong, which opens new doors for researchers to explore how to begin to fix the problem. |
Study reveals imaging approach with potential to detect lung cancer earlier, at the cellular level Posted: 18 May 2022 02:15 PM PDT Researchers have found a way to identify lung cancer at the cellular level in real time during a biopsy, offering promise in the ability to detect the disease earlier and with more confidence. |
Posted: 18 May 2022 02:15 PM PDT Abnormal tumor blood vessels promote cancer progression and treatment resistance. Researchers have developed two approaches to repair tumor blood vessels and they have devised a method to measure the effects of these approaches. Combining the approaches may be an effective strategy for fixing blood vessel abnormalities that make tumors difficult to treat. |
Brain capital: A new investment approach for late-life well-being Posted: 18 May 2022 01:06 PM PDT Within many societies and cultures around the world, older adults are too often undervalued and underappreciated, according to a new article. This exacerbates many key challenges that older adults may face. It also undermines the many positive aspects of late life that are of value at both an individual and societal level. In the article, 'Investing in Late-Life Brain Capital,' a global team of experts propose a new approach to elevate health and well-being by optimizing late-life brain capital. |
Surveillance pathway tells cells when they run low on lipids Posted: 18 May 2022 12:23 PM PDT Researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The findings might someday lead to new ways to combat metabolic disorders and a variety of other health conditions. |
Both nature and nurture contribute to signatures of socioeconomic status in the brain Posted: 18 May 2022 11:07 AM PDT Researchers found that a person's genetics and the environment in which they live contribute to how socioeconomic status shapes the architecture of the brain. |
Technique protects privacy when making online recommendations Posted: 18 May 2022 08:38 AM PDT Researchers have developed a novel privacy-preserving protocol that could enable an algorithm that provides recommendations to guarantee a user's personal information remains secure while ensuring recommendation results are accurate. Their technique is so efficient it can run on a smartphone over a very slow network. |
New ALS 'drug' is more effective than existing ones Posted: 18 May 2022 08:38 AM PDT New preclinical research on the experimental drug, NU-9, to treat ALS shows it is more effective than existing FDA-approved drugs for the disease. More importantly, NU-9 has an enhanced effect when given in combination with those drugs. |
Health screening, genetic tests might identify people at risk of premature heart disease Posted: 18 May 2022 08:38 AM PDT Health screening and genetic tests might identify more than 1 million U.S. adults who have familial hypercholesterolemia, a common genetic disorder that causes elevated bad cholesterol levels, which may lead to premature cardiovascular disease. Identifying familial hypercholesterolemia early in adulthood creates an opportunity for early treatment aimed at preventing heart attack and death, according to a new study. |
New weight-loss intervention targets instinctive desire to eat Posted: 18 May 2022 08:38 AM PDT People who are highly responsive to food lost more weight and kept it off using a new weight loss program that targets internal hunger cues and the ability to resist food. |
New model could improve matches between students and schools Posted: 18 May 2022 07:17 AM PDT Simultaneous and uncoordinated school admissions in situations where students have multiple options can lead to unfilled seats and a lot of stress for families and administrators. To create a fairer, more efficient system, market design researchers created a matchmaking model that draws from game theory, computer science and industrial engineering. |
Researchers discover effective combination immunotherapy for liver cancer Posted: 18 May 2022 07:17 AM PDT Researchers have discovered a specific combination immunotherapy that shows promise in the fight against liver cancer. |
Viral infections during pregnancy affect maternal care behavior Posted: 18 May 2022 07:17 AM PDT Viral infections during pregnancy affect the mother's brain and her postpartum care behavior. These are the findings of a research study in a mouse model. |
Dopamine makes you feel happy, but we probably still have to rewrite the textbooks Posted: 18 May 2022 07:17 AM PDT Researchers have discovered a new piece in the puzzle of the brain's 'feel good' substance, dopamine. According to one of the researchers behind the new study, the discovery may facilitate the development of drugs for i.e. cocaine addiction and ADHD and is most likely to change the general notion of how dopamine is removed from the brain. |
Reliable diagnostics at the tip of your finger Posted: 18 May 2022 05:06 AM PDT Biomarkers are components that may be present in biological samples and are related to specific diseases. Therefore, doctors can analyze biological samples from a patient to check their health condition or to monitor the progress of a specific therapy. Typically, these samples need to be purified and diluted before the analysis, and current medical diagnostic techniques rely on healthcare facilities and laboratories for these routine analyses. This is a lengthy process that requires trained personnel and expensive instrumentation to extract, transport, store, process, and analyze the samples in centralized locations. Moreover, during a period of global crisis like the ongoing pandemic, the pressure of thousands of analysis requests can saturate and collapse the healthcare system. |
How the brain changes during depression treatment Posted: 18 May 2022 05:05 AM PDT Researchers have shown what happens to the brain when a person receives a depression treatment known as repetitive transcranial magnetic stimulation (rTMS). rTMS is a depression treatment typically used when other approaches -- such as medications -- haven't been effective for a patient. By stimulating the dorsolateral pre-frontal cortex, rTMS activates several other regions of the brain involved in multiple functions, from managing emotional responses to memory and motor control. |
Study gives animal testing alternatives a confidence boost Posted: 17 May 2022 06:04 PM PDT As part of a government effort to reduce animal testing, researchers have worked to produce a new protocol for screening skin allergens. The method is potentially cheaper and faster than animal testing, while maintaining a similar performance. |
Timing of heart surgery crucial, research shows Posted: 17 May 2022 06:04 PM PDT The timing of valve replacement heart surgery is crucial, and should be performed earlier than previously thought for people with aortic stenosis, a new study shows. The condition is one of the most common and serious valve disease problems, caused by a narrowing of the aortic valve opening. |
Chemists skew the odds to prevent cancer Posted: 17 May 2022 02:02 PM PDT A theoretical framework shows how to increase the odds of identifying cancer-causing mutations before tumors take hold. Researchers demonstrate that only a few energetically favorable pathways are likely to lead to cancer. |
New protein structures to aid rational drug design Posted: 17 May 2022 02:02 PM PDT In a major advance for rational drug design, chemists have described several protein structures of a crucial player in cellular processes. The advance could bring new ideas for treatments of diseases such as Alzheimer's, AIDS, cancer and others. |
If you take several medications, 'polypharmacy' is a word to know Posted: 17 May 2022 12:46 PM PDT Taking multiple prescription drugs and supplements can be fraught with risk, a new study suggests -- but it's hard for many people to part with their medications. |
mRNA vaccines like Pfizer and Moderna fare better against COVID-19 variants of concern Posted: 17 May 2022 12:18 PM PDT A comparison of four COVID-19 vaccinations shows that messenger RNA (mRNA) vaccines -- Pfizer-BioNTech and Moderna -- perform better against the World Health Organization's variants of concern (VOCs) than viral vector vaccines -- AstraZeneca and J&J/Janssen. Although they all effectively prevent severe disease by VOCs, the research suggests that people receiving a viral vector vaccine are more vulnerable to infection by new variants. |
Concussion symptoms in children may have multiple underlying causes Posted: 17 May 2022 12:18 PM PDT Different types of brain damage caused by a concussion may lead to similar symptoms in children, according to new research. A new way of studying concussions could help develop future treatments. |
Type-I interferon stops immune system 'going rogue' during viral infections Posted: 17 May 2022 12:18 PM PDT Researchers have discovered that Type I interferon (IFN) plays a key role in helping the immune system effectively target viruses, while stopping white blood cells from 'going rogue' and attacking the body's own organs. This opens the way to potential new treatments that can save many lives. |
Time-restricted eating may lower CVD risk for older breast cancer survivors Posted: 17 May 2022 12:18 PM PDT Older breast cancer survivors with cardiometabolic risk factors who restricted food intake to eight hours during the weekday, followed by 16 hours of fasting, lowered their risk of cardiovascular disease (CVD) after a few weeks, according to a new research letter. |
Statins may provide protection against depression Posted: 17 May 2022 10:07 AM PDT Statins have been hailed as a wonder drug; the cholesterol-lowering drugs have been prescribed to tens of millions of people since their approval in the late 1980s to prevent heart attack and stroke. But the drugs may yet have additional benefits, some research has hinted, including on mental health. Now, a new study examines the influence of statins on emotional bias, a marker for risk of depression. |
Scientists see signs of traumatic brain injury in headbutting muskox Posted: 17 May 2022 10:07 AM PDT Scientists saw for the first time hallmarks of concussions and other head trauma in the brains of deceased headbutting animals -- muskoxen and bighorn sheep. The results may contradict the commonly-held belief that ramming animals do not suffer brain injuries and support the notion that studies on animals with brains evolutionarily similar to those of humans may help researchers understand and reduce traumatic brain injuries. |
Friendly fungi announce themselves to their hosts Posted: 17 May 2022 10:07 AM PDT Commensal fungi need to be alive and actively making proteins that stimulate our immune cells to elicit that commensal benefit, according to new findings. |
Protein linked to intellectual disability has complex role Posted: 17 May 2022 08:23 AM PDT Researchers have identified a previously unknown function for the fragile X protein, the loss of which is the leading inherited cause of intellectual disability. The researchers showed that the protein modulates how neurons in the brain's memory center process information, a central part of learning and memory. |
Scientists nail down 'destination' for protein that delivers zinc Posted: 17 May 2022 08:22 AM PDT New research describes a 'chaperone' protein that delivers zinc, a trace element essential for survival in all living things, to where it's needed. The chaperone could be especially important when access to zinc is limited -- for example in nutrient deficient diets and for growing crops on depleted soils. |
How is it possible to remember selfless experiences? Posted: 17 May 2022 08:22 AM PDT People who practice intensive meditation report memories of states in which their sense of self dissolves. Is this at all possible? |
Motivation for sports and school go hand in hand for adolescent athletes Posted: 17 May 2022 08:22 AM PDT Adolescent athletes with high motivation for school also have high motivation for sports. Male students tend to be less interested in school than their female peers, a new study shows. |
Early warning system forecasts who needs critical care for COVID-19 Posted: 17 May 2022 08:22 AM PDT An algorithm can accurately predict which hospitalized patients are at the highest risk of death and require critical care, regardless of immune protection status and virus variant. |
Density, benign disease raise risk of breast cancer Posted: 17 May 2022 08:22 AM PDT Women with dense breast tissue and benign breast disease face an elevated risk of future breast cancer and could benefit from a tailored mammogram screening strategy, according to a large study. |
Posted: 17 May 2022 08:22 AM PDT Adenosine triphosphate (ATP) secreted from sensory neuron-interneuron crosstalk is key to the spreading of inflammation across joints, acting as a neurotransmitter and inflammation enhancer. |
Study identifies cellular 'chaperone' for zinc Posted: 17 May 2022 08:22 AM PDT A team has described and characterized the first zinc metallochaperone: a protein that puts zinc into other 'client' proteins. The findings shed light on the public health issue of zinc deficiency and open an entirely new area of biology for exploration. |
Desktop air curtain system prevents spread of COVID-19 in hospital settings Posted: 17 May 2022 08:22 AM PDT Researchers have developed a desktop air curtain system that blocks all incoming aerosol particles. An air curtain, or air door, is a fan-powered ventilation system that creates an air seal over an entryway, but one challenge in developing smaller air curtains is fully blocking emitted aerosol particles over time because it is difficult to maintain the air wall over a long distance. |
Phage therapy: A model to predict its efficacy against pathogenic bacteria Posted: 17 May 2022 08:17 AM PDT Antibiotic resistance represents a major public health challenge, associated with a high mortality rate. While bacteriophages -- viruses that kill bacteria -- could be a solution for fighting antibiotic-resistant pathogens, various obstacles stand in the way of their clinical development. To overcome them, researchers have developed a model to better predict the efficacy of phage therapy and possibly develop more robust clinical trials. |
U.S. study analyzing tooth survival after root canal in general population Posted: 17 May 2022 06:48 AM PDT Oral health is a public health issue that significantly affects people's overall health. A ground-breaking study of root canal longevity using electronic dental record data from 46,000 root canal patients treated in community dental practices found geographic and procedure disparities, providing real-world insight that can be used to inform dental practice. |
Posted: 17 May 2022 06:48 AM PDT Australia has suffered a significant drop in teenage maths proficiency in the past 20 years -- sliding from 11th in the OECD rankings to 29th place out of 38 countries, prompting widespread debate over potential curriculum changes. One researcher says hand gestures could stop the slide. |
Different subtypes defined in small cell lung cancer Posted: 17 May 2022 06:48 AM PDT Small cell lung cancer (SCLC) is a malignant disease associated with a particularly high mortality rate. According to a new multicenter study, SCLC can be divided into several subgroups in terms of clinical behavior. These subtypes respond differently to chemotherapeutics and targeted drugs. This opens up possibilities for personalized treatment for this type of cancer as well. |
Change of temperature causes whole body reprogramming Posted: 17 May 2022 06:48 AM PDT Human beings, like most organisms, are constantly exposed to alternating colder or warmer temperatures. These environmental variations cause striking metabolic effects and require constant adaptations. While some of these adaptations confer certain beneficial effects on health, the impact of cold and warmth on the various organs in a whole-body context was not known. |
Posted: 17 May 2022 06:48 AM PDT Scientists have demonstrated that a new geochemical archive -- 182Tungsten in banded iron formations -- can be used to simultaneously trace both the evolution of the Earth's mantle and continents throughout Earth's history. This offers new opportunities to better understand the Precambrian Earth in the future. |
Magnetic resonance makes the invisible visible Posted: 17 May 2022 06:48 AM PDT Researchers have developed an advanced NMR (Nuclear Magnetic Resonance) method to monitor fast and complicated biomolecular events such as protein folding. |
Posted: 17 May 2022 05:30 AM PDT Several in-hospital treatments and post-discharge therapies for people who have had an intracerebral hemorrhage, or a bleeding stroke, are not as effective as health care professionals once thought. Compression socks or stockings, anti-seizure medicines and steroid treatment are among treatments with uncertain effectiveness. Studies show that minimally invasive surgical procedures may be a useful addition to treating some bleeding strokes. |
For large bone injuries, it's Sonic hedgehog to the rescue Posted: 17 May 2022 05:30 AM PDT A new study presents intriguing evidence that large bone injuries might trigger a repair strategy in adults that recapitulates elements of skeletal formation in utero. Key to this repair strategy is a gene called Sonic hedgehog. In this study, researchers took a close look at how mice are able to regrow large sections of missing rib -- an ability they share with humans, and one of the most impressive examples of bone regeneration in mammals. To their surprise, the scientists observed an increase in the activity of Sonic hedgehog (Shh), which plays an important role in skeletal formation in embryos, but hasn't previously been linked to injury repair in adults. |
New method melds data to make a 3-D map of cells' activities Posted: 16 May 2022 06:31 PM PDT Engineers are using a cell's surroundings to help biologists make more sense of gene expression information. Their new system could open the door to identifying rare cell types and choosing cancer treatment options with new precision. |
Scientists identify characteristics to better define long COVID Posted: 16 May 2022 06:31 PM PDT Researchers have identified characteristics of people with long COVID and those likely to have it. Scientists used machine learning techniques to analyze an unprecedented collection of electronic health records (EHRs) available for COVID-19 research to better identify who has long COVID. |
Posted: 16 May 2022 06:31 PM PDT The vaccinia virus uses its own machinery and not that of the cell it infects to repair ultraviolet radiation-caused damage to its DNA, according to new research. The virus repurposes an enzyme it uses for copying its DNA to repair the damage. Blocking that enzyme disrupts both the copying and repairing of viral DNA, resulting in a dramatic reduction in new virions. |
Ultra-powerful brain scanners offer hope for treating cognitive symptoms in Parkinson's disease Posted: 16 May 2022 06:31 PM PDT Ultra-powerful 7T MRI scanners could be used to help identify those patients with Parkinson's disease and similar conditions most likely to benefit from new treatments for previously-untreatable symptoms, say scientists. |
Stimulating brain circuits promotes neuron growth in adulthood, improving cognition and mood Posted: 16 May 2022 12:02 PM PDT Targeting specific brain cells modulated memory retrieval and altered anxiety-like behaviors in mice. Essentially, scientists boosted the electrical activity between cells in the hypothalamus and the hippocampus to create new neurons -- an important process called neurogenesis. |
Boost in nerve-growth protein helps explain why running supports brain health Posted: 16 May 2022 10:50 AM PDT Exercise increases levels of a chemical involved in brain cell growth, which bolsters the release of the 'feel good' hormone dopamine, a new study shows. Dopamine is known to play a key role in movement, motivation, and learning. Experts have long understood that regular running raises dopamine activity in the brain and may protect nerve cells from damage. In addition, past research has tied exercise-driven boosts in the dopamine-triggering chemical called brain-derived neurotrophic factor (BDNF) and in dopamine levels to improvements in learning and memory. However, the precise way these three factors interact has until now remained unclear. |
New micro device injects a boost to IVF success Posted: 16 May 2022 09:40 AM PDT A research team has delivered a ground-breaking new micro-device to streamline the only fertility treatment procedure available for men with low sperm counts. |
Electronic skin: Physicist develops multisensory hybrid material Posted: 16 May 2022 09:40 AM PDT Recently developed 'smart skin' is very similar to human skin. It senses pressure, humidity and temperature simultaneously and produces electronic signals. More sensitive robots or more intelligent prostheses are thus conceivable. |
Rare genetic variants not the major contributing factors to common diseases, study finds Posted: 16 May 2022 09:40 AM PDT Although some rare genetic variants can increase the risk of disease markedly for a few individuals, the genetic contribution to common diseases is mostly due to a combination of many common genetic variants with small effects, according to a new study. |
Deaths from alcohol use disorder surged during pandemic, study finds Posted: 16 May 2022 09:40 AM PDT Deaths involving alcohol use disorder increased dramatically during the pandemic, according to a new study. The study also found that young adults 25 to 44 years old experienced the steepest upward trend in alcohol use disorder mortality. |
Perception-based nanosensor platform could advance detection of ovarian cancer Posted: 16 May 2022 09:39 AM PDT Ovarian cancer kills 14,000 women in the United States every year. It's the fifth leading cause of cancer death among women, and it's so deadly, in part, because the disease is hard to catch in its early stages. Patients often don't experience symptoms until the cancer has begun to spread, and there aren't any reliable screening tests for early detection. |
Ethical challenges in microbiome research Posted: 16 May 2022 09:39 AM PDT A human rights activist and a group of anthropologists and human biologists are casting a critical lens on the way that microbiome research is conducted with Indigenous peoples. |
Precursor of spine and brain forms passively Posted: 16 May 2022 09:39 AM PDT Researchers have conducted a detailed study of neurulation -- how the neural tube forms during embryonic development. They conclude that this happens less actively than previously thought. This also has implications for understanding defects such as spina bifida. |
CRISPR-Cas9 gene editing approach can alter the social behavior of animals Posted: 16 May 2022 07:46 AM PDT New gene-editing techniques are shedding light on how hormones impact social behavior in animals and possibly, humans. |
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