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'Boot camp' enzyme prevents autoimmune conditions Posted: 31 Jan 2022 03:58 PM PST Researchers have identified an enzyme in the thymus that is essential for immune T cells to correctly identify threats, safeguarding them from going rogue and attacking healthy tissue in the body. |
Brain function boosted by daily physical activity in middle-aged, older adults Posted: 31 Jan 2022 01:42 PM PST A new study finds brain function boosted by daily exercise in middle-aged and older adults. |
Protein machinery of respiration becomes visible Posted: 31 Jan 2022 12:33 PM PST Researchers provide high-resolution electron microscopy analysis of the molecular machinery within the respiratory chain. |
The two types of climate coping and what they mean for your health Posted: 31 Jan 2022 12:32 PM PST When it comes to coping with climate change, there may be two types of people: those who take action to try to improve the environment and those who don't bother because they don't believe their actions will make a difference. Knowing who's who could help policymakers communicate more effectively about environmental issues, new research suggests. |
Precisely opening a gate to the brain in mice Posted: 31 Jan 2022 11:02 AM PST Researchers developed a technique in laboratory animals to consistently and reproducibly open the blood-brain barrier. This barrier serves as a barricade securing the brain from the external world blocking out certain environmental toxins, but also prevents drug therapies from reaching their intended targets. The new technique is based on a routine procedure for removing clots from the brain's arteries in patients. Their paper essentially provides a roadmap for other researchers to develop and test new therapies for brain diseases. |
Machine learning fine-tunes flash graphene Posted: 31 Jan 2022 10:28 AM PST Scientists are using machine learning techniques to streamline the process of synthesizing graphene from waste through flash Joule heating. |
Key growth factor protects gut from inflammatory bowel disease Posted: 31 Jan 2022 10:28 AM PST A growth factor protein produced by rare immune cells in the intestine can protect against the effects of inflammatory bowel disease (IBD), according to a new discovery. |
Burst of radiation and vesicles-based immunotherapy suppress brain cancer growth Posted: 31 Jan 2022 10:28 AM PST The priming of glioblastoma with a burst of radiation increased dramatically the uptake of extracellular vesicles-based immunotherapy by the tumor and the surrounding microenvironment, halting tumor growth, inducing anti-tumor immunity, and prolonging survival in animal models. In glioblastomas primed with radiation, extracellular vesicles allowed the immunotherapy to cross the blood-brain barrier, recruiting immune cells to the tumor site and reversing the expression of PD-L1, the protein responsible for immunosuppression of the larger tumor environment. |
Simplified antibiotic may set the stage for antitumor treatments Posted: 31 Jan 2022 08:05 AM PST Garden soil houses a variety of bacteria and their natural byproducts -- including one that may help halt tumor growth. Lankacidins are molecules that can be isolated from Strepomyces rochei, a common bacterium in soil. In addition to antimicrobial properties, a type of lankacidins, called lankacidin C, can inhibit tumor activity in various cancer cell lines, including leukemia, melanoma, ovarian and breast cancers. Lankacidin C offers a potential foundation on which to design anticancer drugs, but its structure is complicated and difficult to manipulate, according to an international research group. The same group recently identified where antitumor activity is housed on the molecule and has now used that information to simplify lankacidin as a potential starting point to engineer treatments. |
New imaging method reveals causes of cerebral oedema Posted: 31 Jan 2022 08:05 AM PST Cerebral oedema is a dangerous complication in many brain-related conditions such as strokes. Researchers have now developed a new measurement method that enables a better understanding of the cellular causes of cerebral oedema. According to a new study, the TRPV4 ion channel in particular plays an important role. |
Depression and anxiety spiked in pregnant women during COVID-19 pandemic, research shows Posted: 31 Jan 2022 08:04 AM PST The COVID-19 pandemic caused a spike in depression and anxiety in expectant mums, a new study has revealed. There was an increase in reported depression rates of 30 per cent from pre-pandemic levels, from 17 per cent to 47 per cent -- with anxiety rates also jumping up 37 per cent in expecting mothers to 60 per cent. |
'Traveling' nature of brain waves may help working memory work Posted: 31 Jan 2022 08:04 AM PST The act of holding information in mind is accompanied by coordination of rotating brain waves in the prefrontal cortex, a phenomenon which might confer specific advantages, a new study suggests. |
Making RNA vaccines easier to swallow Posted: 31 Jan 2022 08:04 AM PST Researchers developed a way to deliver RNA in a capsule that can be swallowed, which could make RNA vaccines easier to tolerate. It could also make it easier to deliver other kinds of therapeutic RNA or DNA directly to the digestive tract, to help treat gastrointestinal disorders. |
Activated protein C can protect against age-related cardiac ischemia and reperfusion injury Posted: 31 Jan 2022 07:08 AM PST A preclinical study offers molecular insight into how activated protein C (APC) may improve the tolerance of aging hearts to reperfusion injury -- a potentially adverse effect of treatment for ischemic heart disease |
To keep or not to keep those New Year’s resolutions? Posted: 31 Jan 2022 05:38 AM PST New research suggests that people may not always want help with sticking to their New Year's resolutions. Individuals often make resolutions in January to maintain healthy lifestyle regimes - for example to eat better or exercise more often - then fail to keep them. Behavioural scientists frequently interpret such behaviour as evidence of a conflict between two 'selves' of a person -- a Planner (in charge of self-control) and a Doer (who responds spontaneously to the temptations of the moment). A team of researchers from the Universities of East Anglia (UEA), Warwick, Cardiff and Lancaster in the UK and Passau in Germany investigated how far people identify with their Planners and their Doers. |
Researchers use mobile device data to predict COVID-19 outbreaks Posted: 31 Jan 2022 05:38 AM PST Researchers were able to accurately predict outbreaks of COVID-19 in Connecticut municipalities using anonymous location information from mobile devices, according to a new study. The novel analysis applied in the study could help health officials stem community outbreaks of COVID-19 and allocate testing resources more efficiently, the researchers said. |
Posted: 31 Jan 2022 05:38 AM PST The search to better understand the tremendous range of responses to infection with the COVID-19 virus -- from symptom free to critically ill -- has uncovered in some of the sickest patients a handful of rare structural gene variants involved in body processes, like inflammation, which the virus needs to be successful. |
Mechanical basis for abdominal aortic aneurysm Posted: 28 Jan 2022 11:13 AM PST Researchers have demonstrated mechanobiological changes in vascular smooth muscle cells and identified a key ion channel that is involved in the development of abdominal aortic aneurysm. |
2D Materials could be used to simulate brain synapses in computers Posted: 28 Jan 2022 07:07 AM PST Computers could mimic neural networks in the brain -- and be much more energy efficient -- with a new computer component that mimics how the brain works by acting like a synaptic cell. It's called an electrochemical random access memory (ECRAM), and researchers have developed materials that offer a commercially-viable way to build these components. |
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