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New AI algorithm to improve brain stimulation devices to treat disease Posted: 03 Sep 2021 07:01 PM PDT For millions of people with epilepsy and movement disorders such as Parkinson's disease, electrical stimulation of the brain already is widening treatment possibilities. In the future, electrical stimulation may help people with psychiatric illness and direct brain injuries, such as stroke. |
Imaging single spine structural plasticity at the nanoscale level Posted: 03 Sep 2021 12:11 PM PDT Researchers have developed a new imaging technique capable of visualizing the dynamically changing structure of dendritic spines with unprecedented resolution. By combining two cutting-edge types of microscopies, scientists now have the tools necessary to unravel the ultrastructural complexities of spines during the process of synaptic plasticity. |
Gut bacteria influence brain development Posted: 03 Sep 2021 10:26 AM PDT Extremely premature infants are at a high risk for brain damage. Researchers have now found possible targets for the early treatment of such damage outside the brain: Bacteria in the gut of premature infants may play a key role. The research team found that the overgrowth of the gastrointestinal tract with the bacterium Klebsiella is associated with an increased presence of certain immune cells and the development of neurological damage in premature babies. |
Severe infections during pregnancy associated with complications around childbirth Posted: 03 Sep 2021 10:26 AM PDT Individuals who are hospitalized during pregnancy due to sepsis have higher odds of complications surrounding childbirth, according to a new study. The study found that pregnancies complicated by sepsis were associated with an increased risk of cesarean delivery, postpartum hemorrhage and preterm delivery, highlighting the risk of any severe infection during pregnancy. |
Predicting possible Alzheimer’s with nearly 100 percent accuracy Posted: 03 Sep 2021 10:26 AM PDT Researchers have developed a deep learning-based method that can predict the possible onset of Alzheimer's disease from brain images with an accuracy of over 99 percent. The method was developed while analyzing functional MRI images obtained from 138 subjects and performed better in terms of accuracy, sensitivity and specificity than previously developed methods. |
Statistical model defines ketamine anesthesia’s effects on the brain Posted: 03 Sep 2021 10:26 AM PDT Neuroscientists have developed a statistical framework that rigorously describes the brain state changes that patients experience under ketamine-induced anesthesia. |
Subscription-based payment models may improve access to hepatitis C medications Posted: 03 Sep 2021 10:26 AM PDT Subscription-based payment models (SBPM), a novel approach in which states contract exclusively with a single manufacturer to supply prescriptions at a reduced price, could increase access to these life-saving treatments, according to a new study. In a SBPM, states pay reduced per prescription prices for medications until a certain utilization threshold. After this threshold, the cost of additional prescriptions is essentially zero. |
New model for solving novel problems uses mental map Posted: 03 Sep 2021 10:26 AM PDT How do we make decisions about a situation we have not encountered before? New work shows that we can solve abstract problems in the same way that we can find a novel route between two known locations -- by using an internal cognitive map. |
Engineered ‘mini’ CRISPR genome editing system developed Posted: 03 Sep 2021 10:25 AM PDT Bioengineers have repurposed a 'non-working' CRISPR system to make a smaller version of the genome engineering tool. Its diminutive size should make it easier to deliver into human cells, tissues and the body for gene therapy. |
Secret garden: Drug-resistant pathogen strains meet and evolve on plant bulbs Posted: 03 Sep 2021 06:53 AM PDT Researchers have found that drug-resistant strains of a potentially deadly fungus isolated from a tulip bulb showed evidence of genetic recombination and fungicide resistance. The team revealed that plant bulbs provide a place for strains of the human pathogen Aspergillus fumigatus, which can cause highly lethal fungal infections, to evolve drug resistance. |
Drug cocktail reduces aging-associated disc degeneration Posted: 03 Sep 2021 05:59 AM PDT Therapies that target aging cells early pave the way to easing back pain. |
Exploring the role of gender in scholarly authorship disputes Posted: 02 Sep 2021 02:47 PM PDT A new paper found that women -- as compared to their male counterparts -- receive less credit for the work they put into academic publications, more frequently experience disagreements over authorship, and often end up losing out on opportunities for future collaboration as a result. |
Engineering CAR T cells to deliver endogenous RNA wakes solid tumors to respond to therapy Posted: 02 Sep 2021 02:47 PM PDT A new study shows CAR T cells expressing RN7SL1 can activate the body's natural immune cells against difficult-to-treat cancers. |
Why are only some cells ‘competent’ to form cancer? Posted: 02 Sep 2021 02:47 PM PDT Medical researchers report that melanoma formation depends on something called 'oncogenic competence,' which is the result of a collaboration between the DNA mutations in a cell and the particular set of genes that are turned on in that cell. Cells that are competent to form melanoma are able to access a set of genes that normally are closed off to mature melanocytes (the cells that make melanin and give skin its color). In order to access these locked-up genes, the cells require specific proteins that act as keys. Without them, the cells do not form melanoma, even when they have cancer-associated DNA mutations. |
Rapid and sensitive on-site measurement of antibodies against the COVID-19 virus Posted: 02 Sep 2021 09:50 AM PDT Researchers have developed a diagnostic system that can rapidly and sensitively measure the amount of antibodies in the blood that can protect us from SARS-CoV-2, the virus that causes COVID-19. This achievement is expected to enable efficient and precise testing of SARS-CoV-2 vaccine efficacy at medical facilities. |
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