| Dear Voornaam, Welcome to your first early detection newsletter of 2020. This month were shining a spotlight on some of our recently funded awards and teams who are pushing scientific boundaries in the early detection field. We also have an exciting update to share about a new initiative to improve networking opportunities for early and mid-career researchers working in early detection. See below for more information. Were pleased to announce that applications are now open for our next sandpit workshop in June. The workshop will bring together multidisciplinary researchers to stimulate revolutionary ideas for the early detection of pancreatic cancer and award pilot funding to the best of those ideas. Head to our website for more information and please share this opportunity with anyone you think may be interested. This year were excited to be hosting the Early Detection of Cancer Conference in London. Delivered in partnership with OSHU and the Canary Center at Stanford University, our programme for 2020 is taking shape. Please see below for more details and we hope to see you there. Finally, please dont forget that the submission deadlines for our Primer and Programme Awards are next month. Best wishes, David Crosby, Head of Early Detection Research Cancer Research UK |
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UPCOMING FUNDING DEADLINES |
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| | | Final submission deadline 07 March 2020 |
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| | | Preliminary submission 28 March 2020 |
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| | | Application deadline 15 April 2020 |
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| | | Final submission 11 June 2020 |
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 EARLY DETECTION OF CANCER CONFERENCE, 68 OCT 2020 Were excited to mark the return of the Early Detection of Cancer Conference to the UK, with this years meeting taking place at Central Hall Westminster, London. Our stellar scientific programme committee of Professor Ros Eeles (ICR), Professor Paul Spellman (OHSU), and Professor Tom Soh (Stanford) have put together 4 sessions that will highlight cutting-edge early detection research. Topics will include: - The future of designing and delivering early detection trials
- Making the most of big data early detection and artificial intelligence
Registration is now open. We look forward to welcoming the early detection community to this flagship event. |
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|  APPLICATIONS OPEN FOR OUR NEXT SANDPIT WORKSHOP We're teaming up with Pancreatic Cancer UK and The Engineering and Physical Sciences Research Council to run the next Early Detection of Cancer sandpit workshop from 710 June.This time, well be exploring novel technological approaches for the early detection of pancreatic cancer. This 3-day residential event aims to stimulate new and revolutionary research ideas by bringing together researchers from different disciplines that would not normally interact to inspire creative thinking.
We welcome applications from a range of academic, industry and community sectors to this intensive residential event. Prior experience in early detection of cancer is not required.
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RECENTLY FUNDED AWARDS In its sixth funding round, the Early Detection Committee funded 1 Programme, 5 Projects and 9 Primers, awarding 6.3m to support early detection of cancer research. Ellie Barnes at the University of Oxford was awarded 2.6m over 5 years by the Committee. Her programme aims to detect hepatocellular liver cancer (HCC) earlier by characterising pre-cancerous liver microenvironment, testing the hypothesis that inflammation/immune response drives transformation. Philip Dunne at Queens University Belfast was awarded 485,000 over 3 years to develop a molecular risk stratifier in patients with screening detected T1 colorectal cancer, to better understand which of these tumours are born to be bad. Kevin Litchfield, an early career researcher at University College London, was awarded 100,000 for a year to study immune dysfunction as a biomarker for the early detection of lung cancer development. |
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WHO WEVE FUNDED VIA THE DIGITAL PATHOLOGY AND AI SANDPIT Together with The Science and Technology Facilities Council, weve awarded 300,000 to 3 high-risk, high-reward projects from new multidisciplinary teams of clinicians, pathologists and computational scientists assembled at Novembers sandpit workshop. |
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 Team Haem-AI Led by Daniel Royston at the University of Oxford, Team Haem-AI will utilise image-based computational approaches to develop quantitative criteria for the early detection of myeloproliferative neoplasms and facilitate clinical decision making. |
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|  Team PathNAV Led by Marnix Jansen at University College London, Team PathNav will exploit user generated digital pathology data (e.g. slide coordinates, zoom level, time stamps) from a Barretts dysplasia consensus study to develop and train a neural network for automated image analysis. |
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|  Team PRISM Led by Jan Lukas Robertus at Imperial College London, Team PRISM will deploy machine learning techniques to identify phenotypic markers of pre-malignant change in mesothelial cells to aid in tool development for early cancer detection in mesothelioma. |
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CRUK EARLY AND MID-CAREER RESEARCHER NETWORK FOR EARLY DETECTION OF CANCER Were establishing a network for early and mid-career researchers working in early detection or with an interest in this area. The network will develop workshops and events to benefit the research activities and career progression of early and mid-career researchers and will provide a hub for early detection discussion. Clinical and non-clinical researchers from all research fields are welcome to join the network. We will be supporting the activities and initiatives of the network, which will be focused around 3 main hubs: Scotland, North of England and South of England.
Well be having a kick off meeting to organise the North of England hub at the University of Liverpool on 17 March from 14pm. If you would like to join, please contact Ana Lopez at [email protected]
Watch this space for further updates about the network and activity at the other hubs. |
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| | INTERNATIONAL ALLIANCE FOR CANCER EARLY DETECTION SUMMER SCHOOL, 1417 JULY, PORTLAND Now in its second year, the summer school event is presented by the International Alliance for Cancer Early Detection (ACED). Open to all researchers, it's designed for those who are developing new technologies and interventions for the early detection of cancer and those who are interested in exploring this rapidly expanding and exciting field. The event focuses on the scientific, clinical and policy challenges of developing and validating new screening technologies and interventions for the early detection of cancer. |
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| | | University of Liverpool 24 March 2020 |
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| | | Barts Cancer Institute 04 May 2020 |
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| | | RSC-CRUK Networking Event, Measuring Cancer Earlier
Burlington House, London, UK 12 June 2020 |
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