Elucidating PROTAC MoA with live cell kinetic monitoring of ternary complex formation and target protein ubiquitination

PROteolysis TArgeting Chimeras (PROTACs) are small molecules that selectively induce protein degradation and are seen as promising therapeutics.


In this application note, NanoBRET™ is used to measure targeted protein degradation in live cells upon PROTAC treatment.

 
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