Cancer Research UK

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Cancer Research UK
Hero graphic for the weekly CRUK research update newsletter
 

Dear Voornaam,

To accelerate progress in cancer research, we need the worlds brightest minds to come together to tackle the most complex questions.

Today, Im delighted to share the new set of nine Cancer Grand Challenges. International teams are invited to apply for up to 20m funding. From establishing the mechanisms through which obesity and physical activity influence cancer risk to understanding how genetics, biology, and social determinants affect outcomes in diverse populations these new challenges are the obstacles that no one scientist, institution, or country can solve alone.

Cancer Grand Challenges, an initiative we co-founded with the National Cancer Institute, provides global research teams with funding to come together, think differently and take on cancer's toughest challenges.

This year's challenges were identified following a rigorous grassroots process, involving workshops and consultations with the global cancer research community and people affected by cancer. Out of the 300 ideas submitted, the Cancer Grand Challenges Scientific Committee recommended a set of nine complex challenges, that they believe can be solved.


Expressions of interest are now open for international teams to apply until 22 June, with the shortlisted teams announced in August.

Explore the newest Cancer Grand Challenges in more detail below.

Kind regards,
Dr Iain Foulkes
Executive Director Research & Innovation
CEO Cancer Research Horizons
Cancer Research UK

 
CGC header image
 
CGC early-onset image link
 

EARLY-ONSET CANCERS

Challenge: determine why the incidence of early-onset cancers in adults is rising globally

Explore the challenge
CGC ageing cancer image link
 

AGEING AND CANCER

Challenge: decipher the functional basis underlying the association between ageing somatic tissues and cancer

Explore the challenge
 
CGC tumours children image link
 

SOLID TUMOURS IN CHILDREN

Challenge: develop therapeutics to target oncogenic drivers of solid tumours in children

Explore the challenge
CGC obesity cancer risk image link
 

OBESITY, PHYSICAL ACTIVITY AND CANCER

Challenge: determine the mechanisms through which obesity and physical activity influence cancer risk

Explore the challenge
 
CGC neurotoxicity image link

CHEMOTHERAPY-INDUCED NEUROTOXICITIES

Challenge: understand and prevent chemotherapy-induced neurotoxicity and neuropathy

Explore the challenge
 
CGC cell plasticity image link
 

CANCER CELL PLASTICITY

Challenge: understand cancer cell plasticity and its contribution to the development of pan-therapeutic resistance in cancer

Explore the challenge
CGC cancer inequities image link
 

CANCER INEQUITIES

Challenge: understand the mechanisms through which genetics, biology, and social determinants affect cancer risk and outcomes in diverse populations, to motivate interventions to reduce cancer inequities

Explore the challenge
 
CGC retrotransposable elements image link
 

RETROTRANSPOSABLE ELEMENTS

Challenge: understand the roles of retrotransposable elements in cancer

Explore the challenge
CGC t-cell receptor image link
 

T-CELL RECEPTORS

Challenge: decipher the T-cell receptor cancer-recognition code

Explore the challenge
 
 

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