China jails "gene-edited babies" scientist for three years

China jails "gene-edited babies" scientist for three years

1. China jails 'gene-edited babies' scientist for three years
2. Heritable genome modification: A criminal enterprise: Center for Genetics and Society comment on prison term for “CRISPR babies” scientist
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1. China jails 'gene-edited babies' scientist for three years

BBC News, 30 December 2019
https://www.bbc.co.uk/news/world-asia-china-50944461
A scientist in China who said he had created the world's first gene-edited babies has been jailed for three years.
He Jiankui was convicted of violating a government ban by carrying out his own experiments on human embryos, to try to give them protection against HIV.
He was globally condemned when he announced his experiments, and the birth of twin babies, last November.
Xinhua news agency said a third baby was also born at the same time, which had not previously been confirmed.
The local government in Guangdong province said it was keeping the babies under medical observation.
As well as the prison sentence, He was fined three million yuan ($430,000; £328,000).
The court also handed lower sentences to two men, Zhang Renli and Qin Jinzhou, for conspiring with He to carry out the experiments.
A court in Shenzhen said the men had acted "in the pursuit of personal fame and gain", and had seriously "disrupted medical order", Xinhua news agency reported.
"They've crossed the bottom line of ethics in scientific research and medical ethics," the court added.
What happened last year?
He announced the birth of gene-edited twins called Lula and Nana in a video, filmed by Associated Press, in November 2018.
Describing his experiments, He said: "I understand my work will be controversial - but I believe families need this technology and I'm willing to take the criticism for them."
After the video was released, the backlash from the science community both in China and around the world was swift and forceful.
The Chinese government placed He under police investigation and ordered his research work be stopped.
He was also fired by the university where he was an associate professor, the Southern University of Science and Technology in Shenzhen.
The Chinese Academy of Science released a statement about He, saying it "firmly opposed" gene editing on humans.
"Under current circumstances, gene editing in human embryos still involves various unresolved technical issues, might lead to unforeseen risks, and violates the consensus of the international scientific community," the statement added.
How did the experiment work?
He was targeting a gene called CCR5.
This is a set of genetic instructions that are important for a functioning immune system - but they are also the doorway that human immunodeficiency virus (HIV) walks through to infect cells.
Mutations to CCR5 essentially lock the door and give people resistance to HIV.
According to South China Morning Post, He recruited seven heterosexual couples who wanted children to take part in the study. The men were all living with HIV, while the women were not.
The professor made embryos in an IVF clinic, and used gene-editing technology known as CRISPR-Cas9 to change the CCR5 gene.
He then forged documents in order to pass a mandatory ethics review, and fabricated information so that medical doctors would unknowingly implant the gene-edited embryos into two women.
What are the repercussions?
The full consequences of gene-editing babies are unclear, but the effects could be permanent.
If the babies grow up to have children of their own, any genetic modifications could be passed down through the generations. This could potentially introduce a lasting change to the human race.
This is even more complicated in the case of He's experiment.
Earlier this month, when He's original research was published for the first time, scientists said the results did not show what He had said they did.
While He had targeted the correct gene, they said, he had not created the exact mutation associated with resistance to HIV.
Instead, He created previously-unseen genetic edits - the effects of which are currently unknown.
Prof Robin Lovell-Badge, from the UK-based Francis Crick Institute, told BBC News that they "just can't tell" what the effects of these edits will be.
"There have never been any studies on these specific mutations because they haven't existed before," he said.
"He was very foolish. He thought he knew better, but the techniques are just not there yet to do [genome editing] safely and efficiently."
The long-term effects remain to be seen - but, Prof Lovell-Badge added, the main concern is "whether the three babies born are going to be healthy and looked after well".
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2. Heritable genome modification: A criminal enterprise

Center for Genetics and Society, 31 Dec 2019
https://www.geneticsandsociety.org/press-statement/center-genetics-and-society-comment-prison-term-crispr-babies-scientist
China has announced the sentencing of He Jiankui, the scientist whose attempts at heritable genome editing led to the births of three babies. The Center for Genetics and Society welcomes this strong stand by the Chinese government, and notes the need for the few countries that currently lack clear and specific prohibitions on heritable genome editing to adopt them.

This sentencing of a former associate professor of biology in Shenzhen, China and a principal in several biotech companies, along with two of his collaborators, provides an opportunity to reflect on the broader debate about whether human gene editing should ever be used for reproductive purposes.

CGS Executive Director Marcy Darnovsky, PhD, said:

The reckless and self-serving acts of He Jiankui and his associates should highlight the broader and deeper risks – and the pointlessness – of any proposal to use gene editing in human reproduction. There is no convincing medical reason to ever go down this road, since safe existing methods can prevent the transmission of serious inherited diseases.

As both the He Jiankui episode and disturbing comments from a few other scientists illustrate, heritable genome editing would likely be used in half-cocked efforts to create genetically “upgraded” children. If marketed to the affluent, it could even lead to a world divided into genetic “haves” and “have nots.”

Katie Hasson, PhD, CGS Program Director on Genetic Justice, commented:

The Chinese authorities appear to be moving toward stronger and clearer laws prohibiting heritable genome editing. Our legislators should do the same and join the dozens of nations that have already adopted binding laws specifically prohibiting gene editing for reproductive uses, while supporting the development of gene therapies to treat existing patients.

But the risks of heritable genome editing extend beyond individual countries. It is a global concern and therefore a global responsibility. Broad and inclusive public deliberation is needed on this issue that could potentially affect all of us. We are confident that a meaningful debate will result in broad societal consensus that heritable genome editing is unneeded and would pose unacceptable societal dangers.

Several questions remain, and should be answered in the public interest. The anonymity of the children who developed from the gene-edited embryos (the existence of a third has now been confirmed) is entirely appropriate, but the previously reported technical failures of the gene editing deserve further scientific analysis, as does the subsequent health of the babies.

Many scientists, bioethicists, biotech industry figures, and public interest advocates agree that heritable genome editing should be prohibited. A civil society statement with more than 100 signatures released just after He Jiankui’s announcement in November 2018 warned that without enforceable prohibitions, a runaway international competition for primacy in human inheritable genetic engineering could exacerbate social inequality and discrimination. The statement noted that this would be especially dangerous now, at a time of resurgent racism, xenophobia, and socio-economic disparity.

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