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| Scientists find 'trigger' of rare AZ vaccine blood clot |
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What led to extremely rare blood clots after the Oxford-AstraZeneca Covid vaccine has been somewhat of a mystery. Scientists have been investigating and now believe they have found the cause, the "trigger". Researchers trying to establish why clots - linked to 73 deaths out of nearly 50 million doses of AstraZeneca given in the UK - have occurred say it's linked to a protein in the blood. That protein is attracted to a key component of the vaccine which, they believe, kicks off a chain reaction involving the immune system. AstraZeneca stresses clots are more likely to occur because of a Covid infection rather than the vaccine and say although the "research is not definitive it offers interesting insights". The pharmaceutical company is, however, "exploring ways to leverage these findings as part of our efforts to remove this extremely rare side effect".
Finding the "trigger" of the clots, according to researcher Prof Alan Parker, leads to more steps and further investigation. "You could never have predicted it would have happened and the chances are vanishingly small, so we need to remember the bigger picture of the number of lives this vaccine has saved," he adds. The Oxford-AstraZeneca vaccine is thought to have saved about a million lives and, along with other jabs from companies such as Pfizer, many more deaths have been prevented. It’s emerged that the government has signed contracts for more vaccines - 114 million additional doses. They are not for the booster programme, says our health correspondent Nick Triggle, it’s about securing vaccination for next winter and beyond. The deal for the additional Pfizer-BioNTech and Moderna doses covers 2022 and 2023. Without vaccines, things would be very different, according to Pfizer chief executive Albert Bourla. "The bottom line is millions of lives were saved," he told us in an exclusive interview. | |
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| Top US judges signal support for abortion limits |
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| Abortion rights in the US could change as top judges in the country appear poised to accept a law that would bar terminations after 15 weeks of pregnancy, even in cases of rape or incest. The case in the Supreme Court that has been called the most conservative leaning in modern US history is being considered and indications show a majority backed upholding that Mississippi law. There were about 630,000 reported abortions in 2019 - an 18% decrease in terminations compared with 2010. A change in the law may mean millions of women would lose abortion access, and experts warn of an increase in maternal mortality if restrictions come into force. However anti-abortion activists say they are urging the courts to protect unborn children. A ruling is expected in June. | |
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| I didn’t pull the trigger - Alec Baldwin |
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| "I would never point a gun at anyone and pull a trigger at them. Never," says actor Alec Baldwin. He reveals this in his first sit-down interview after cinematographer Halyna Hutchins was fatally injured on the set of his film Rust. She was shot during a rehearsal with what Mr Baldwin believed to be a "cold" - or safe - gun in New Mexico. The gun is believed to have fired when he removed it from a holster during rehearsals for a forthcoming scene. Ms Hutchins died in hospital following the shooting that also resulted in director Joel Souza being injured. The 80-minute interview with Mr Baldwin was "raw", according to George Stephanopoulos from ABC News, who describes the actor as "devastated" yet "very candid" and "forthcoming". "I've done thousands of interviews in the last 20 years at ABC," says Mr Stephanopoulos. "This was the most intense I've ever experienced." | |
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| |  | | | John Yan has decided to start giving away at least 15% of his annual salary, despite it meaning that he'll have to work longer into his old age. The 27-year-old software engineer began donating part of his wages in 2019, pledging 1% that year, before raising it to 3% in 2020, and then a big jump to 15% in 2021.
"In practical terms this commitment means I'm not going to retire early," says Mr Yan, who lives and works in New York. He is donating the money via a global scheme called Giving What We Can. This encourages people to sign up as a member and pledge to give 10% of their earnings to charity. Members can either donate directly to a charity of their choosing, or pick from a recommended list. | |
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| | Suzanne Bearne | Business reporter | |
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| | | | Coronavirus jabs and government guidance about Christmas parties dominates the papers this morning. On vaccines, the i reveals the UK has bought 114 million doses to last until 2023. The Daily Telegraph puts the story in another way, saying that amounts to "two more rounds" of the jab. Meanwhile, the Guardian claims the booster drive may mean GPs stop monitoring millions of patients. The papers focusing on Christmas include the Daily Mail which has the headline "Stop being Christmas killjoys, ministers!". It takes this position following a warning not to kiss under the mistletoe and to take lateral flow tests before parties despite cases of the Omicron variant being "mild". Read the newspaper review in full here. | |
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| | | Military Ministry of Defence aims to double female recruits by 2030 |
| | | | | | Farming New plan to pay farmers who protect winter soil |
| | | | Covid Don't kiss strangers under mistletoe - minister |
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| If you watch one thing today |
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| If you listen to one thing today |
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| If you read one thing today |
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| Need something different? |
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| Sending in a CV, filling in an application form, using a recruiter or finding a contact at the place you want to work is usually how most of us go about finding a job. But after having no luck and getting fed up, one banking and finance graduate decided to take matters into his own hands. He created a pop-up stand outside a London Underground station, conquered his nerves and began chatting and pitching himself to potential employers - and his luck soon changed. Here’s his story.
Now you’ll see these on the pitch, and they’ll be around for longer than you expect. Premier League side Brentford is planning to keep the same home kit for two seasons for sustainability and to save fans cash. Gavin Hope, who runs Football Kit Geek, says it’s the start of something, but will this encourage others football clubs follow suit? Find out here.
And finally, this job won’t suit everyone and it requires a lot of patience. Just capturing 20 seconds of sounds from animals in their natural habitat often means hours of staying still and solitude. Martyn Stewart been doing just that for the past 55 years, building up one of the largest private collections of natural sound in the world. Take a look. | |
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| On this day |  |
| | | 1988 A search is under way for thousands of people feared dead after a devastating cyclone in Bangladesh. |
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| Let us know what you think of this newsletter by emailing [email protected]. If you’d like to recommend it to a friend, forward this email. New subscribers can sign up here. | |
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