Pfizer reports patient death in early-stage Duchenne gene therapy trial, halts enrollment Sanofi gambles $1B upfront on preclinical oncology biotech, bagging Amunix for its pipeline of T-cell engagers Fierce Biotech's top 10 editor's picks for 2021 The Alzheimer's debate may not seem positive, but AC Immune's CEO promises it's been a breakthrough year Lilly's atopic dermatitis med scores another late-stage win in attempt to outdo Dupixent PhaseBio blames COVID-19 disruption as cardiovascular study axed Abandoned by Amgen, Cytokinetics lands $50M upfront deal for Chinese rights to heart failure prospect No data, no problem. Senti will go public in $296M SPAC deal before hitting the clinic Aptose finally ditches APTO-253 after 3-year clinical hold, phase 1 dud Takeda-backed Ambys tops out series A with $47M more to test liver cell therapy in 2023 Acadia slims Nuplazid label expansion bid in hopes of clinching Alzheimer's dementia nod without extra studies Goldman Sachs forecasts positive outlook for insurers in 2022, buoyed by shift to value-based care Featured Story | By Annalee Armstrong Pfizer reported the death of a young male patient who was participating in an an early-stage trial for the Big Pharma’s Duchenne muscular dystrophy gene therapy. The company paused screening and dosing in the study while it works with the trial site investigator to figure out what happened. read more |
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Top Stories By Nick Paul Taylor Sanofi is betting $1 billion on a preclinical pipeline of anti-cancer T-cell engagers. The upfront outlay, plus up to $225 million in milestones, is set to give Sanofi ownership of West Coast immuno-oncology player Amunix Pharmaceuticals. read more By Annalee Armstrong Senior Editor Annalee Armstrong recaps her top 10 best stories of the year produced by the Fierce Biotech team. read more By Annalee Armstrong After showing for the first time the potential of an anti-tau therapy in Alzheimer’s disease, Roche-partnered AC Immune is capitalizing on the massive moment underway in research for the neurodegenerative disease. read more By Annalee Armstrong Watch out, Sanofi and Regeneron. Eli Lilly’s Dupixent rival has posted another round of data showing improvement in atopic dermatitis when combined with topical corticosteroids in a phase 3 trial. read more By Annalee Armstrong PhaseBio is blaming the impact of COVID-19 on manufacturing for the decision to end development of a mid-stage cardiovascular disease treatment. read more By Nick Paul Taylor Cytokinetics has found another company that still sees a future for its heart failure prospect omecamtiv mecarbil. After losing partnerships with Amgen and Servier in quick succession, Cytokinetics has sold the Chinese rights to the candidate to Ji Xing Pharmaceuticals. read more By Annalee Armstrong Senti Biosciences is hopping on the SPAC track with a deal that will provide $296 million in proceeds for the preclinical biotech to move its gene circuit engineered cell and gene therapies toward human trials. read more By Annalee Armstrong The writing was perhaps on the wall for this one back in 2018: Aptose Biosciences has decided to end clinical development of the c-Myc inhibitor APTO-253, a therapy that was the subject of a three-year FDA clinical hold. read more By Kyle LaHucik Ambys Medicines wants to go after diseases impacting the liver, a key regenerative organ, with cell therapies. The Takeda-partnered biotech snagged $47 million from the Japanese Pharma and venture shops to test its asset in human trials in 2023. read more By Fraiser Kansteiner After suffering a surprise rejection from the FDA in April, Acadia Pharmaceuticals is making another bid to expand the scope of its Parkinson’s disease med Nuplazid—and it hopes to do so without running additional trials. read more By Heather Landi Global investment bank Goldman Sachs projects that the pursuit of value-based care could potentially bring significant payoff for big insurers in 2022. For the next two years, analysts Nathan Rich and Lindsay Golub estimate a potential 13% annual earnings per share growth for large-cap managed care organizations, more than double the firm’s 6% projection for S&P EPS growth, according to a recent report. read more Resources Sponsored by: Thermo Fisher Scientific Learn how a CDMO partnered with Thermo Fisher Scientific to manage high-volume process liquid and buffer preparation scale-up. Download the free case study from Thermo Fisher Scientific Sponsored by: WIRB - Copernicus Group Sites receiving augmentation support enroll more than 30,000 patients in just over three months. See how additional site resources can make a difference. Sponsored by: BBK Worldwide New survey results and insights help clinical trial sponsors improve diversity and inclusion, enroll faster, and keep participants engaged longer. Sponsored by: GLG A major Korean biopharmaceutical company wanted to gather unbiased opinions on a new cancer treatment product. 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