Novartis brings on first TIGIT drug in massive billion-dollar biobucks deal with BeiGene This is just the Spark: Roche's new gene therapy manufacturing center leaves space for growth Fierce Biotech’s top 10 data readouts in 2022 Roche adds to Genentech's ophthalmology program with $720M in biobucks for Lineage Cell Therapeutics' asset Novartis suffers shock setback as Xolair successor fails phase 3 Forbion arms biotech to stop sudden cardiac death, leading $35M round to fund phase 2 trial of Armgo's pipeline-in-a-product A colon growth hormone could pave way for treating aging-related disorders Biogen halves Aduhelm's price and plots cost cuts as Medicare decision on controversial Alzheimer's drug nears Mental health startup Cerebral teams with Alto Neuroscience to bring 'precision psychiatry' to patients' homes FDA clears muscle stimulator for increasing blood flow in the lower legs Bluebird bio hits FDA clinical hold—again—for gene therapy in sickle cell disease Featured Story | By Annalee Armstrong After watching Gilead and Roche dive deeper into TIGIT immunotherapies, Novartis is heading straight for the senior class. The Swiss pharma is getting in on the game via a blockbuster deal with BeiGene, which could ultimately net $1 billion for a late-stage asset. read more |
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Top Stories By Annalee Armstrong Since coming under the Roche banner in 2019, Spark Therapeutics has been working towards a massive expansion of its manufacturing capacity. Those efforts came to fruition Friday, and the companies intend to leave a few rooms open in the new $575 million facility for future growth. read more By Phil Taylor There are a number of potential blockbuster drugs on the list, but it’s not all about revenue potential. Many of the compounds are high-risk, high-reward candidates trying to push the boundaries of drug treatment. read more By Annalee Armstrong Roche’s Genentech has signed what could be a $720 million deal for Lineage Cell Therapeutics’ cell therapy for a range of eye disorders. Lineage is developing a retinal pigment epithelium cell therapy in dry age-related macular degeneration with geographic atrophy. read more By Nick Paul Taylor Novartis’ attempt to establish ligelizumab as the successor to its blockbuster Xolair has hit a roadblock. The new molecule failed to better the old stager in a phase 3 clinical trial, leaving Novartis uncertain of its next steps for the program. read more By Nick Paul Taylor Armgo Pharma is returning to its roots to deliver clinical proof of concept for its pipeline-in-a-product. After shifting focus from abnormal heart rhythm to neuromuscular disorders, Armgo is now returning to arrhythmias for its push into phase 2—and has armed itself with $35 million from Forbion and other VCs to go after the indication. read more By Kyle LaHucik Researchers say they have found a growth hormone in the colon that helps damage DNA, which aides in the aging process. The finding could lead to new therapeutic approaches to aging-associated disorders like cancer. read more By Angus Liu As the Centers for Medicare & Medicaid Services is expected to make a coverage decision on Biogen’s controversial Alzheimer’s drug Aduhelm, the biotech is making an unexpected goodwill gesture—and an expected restructuring—as it faces pressure from all fronts. read more By Heather Landi Mental health startup Cerebral has inked a partnership with Alto Neuroscience to bring clinical trials for depression to patients’ homes. Through the collaboration, Cerebral is able to offer its network of members the opportunity to participate in at-home clinical research utilizing Alto’s biomarker platform and targeted drug candidates. read more By Conor Hale The FDA greenlighted U.K.-based Sky Medical's wearable electrical muscle stimulator to help stave off some of the symptoms of chronically blocked vessels such as varicose veins and blood pooling in the legs. The geko device, about the size of a wristwatch, stimulates a central nerve located at the top of the shin to increase circulation. read more By Angus Liu Bluebird bio simply can’t catch a break. Just half a year after coming off an FDA clinical hold, development of the biotech’s blood disease gene therapy LentiGlobin has once again been halted, this time in sickle cell disease patients under the age of 18. read more Resources Sponsored by: Thermo Fisher Scientific Learn how a CDMO partnered with Thermo Fisher Scientific to manage high-volume process liquid and buffer preparation scale-up. Download the free case study from Thermo Fisher Scientific Sponsored by: WIRB - Copernicus Group Sites receiving augmentation support enroll more than 30,000 patients in just over three months. See how additional site resources can make a difference. 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