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December 07, 2018

Today's Rundown

Featured Story

Moderna’s cash juggernaut rolls on with record $604M IPO

Moderna’s IPO always looked like a record breaker for biotech and came in even larger than expected at $604 million, valuing the company at an eye-watering $7.9 billion.

Top Stories

AstraZeneca’s tremelimumab fails another phase 3 cancer trial

AstraZeneca’s tremelimumab has come up short in another phase 3 trial. Having failed to improve outcomes in metastatic non-small cell lung cancer, the anti-CTLA4 antibody has now missed the primary endpoint in a phase 3 advanced head and neck cancer trial.

DiaMedica pulls off IPO to fund midphase stroke trial

DiaMedica Therapeutics has wrapped up its IPO. The offering gives DiaMedica the cash to take its lead candidate through phase 2 trials in acute ischemic stroke and chronic kidney disease.

Eisai, UCL extend neuro pact, gear up for Alzheimer’s phase 1

Six years after Eisai and University College London teamed up to discover new treatments for neurological diseases, they are moving their first candidate into the clinic: a tau-targeting monoclonal antibody for Alzheimer’s disease.

Regenerating insulin-producing cells with zinc could tackle the underlying cause of diabetes

The ability to regenerate insulin-producing cells in the pancreas would do the job, but that has so far proven to be an elusive target. A team of Stanford University scientists is now searching for a solution in a common nutrient: zinc.

Neurimmune’s anti-SOD1 antibody shows promise in ALS mouse studies

Neurimmune is best known for its Alzheimer's partnership with Biogen to develop aducanumab. Now its scientists have used the same technology to design a recombinant human monoclonal antibody that shows potential as treatment for amyotrophic lateral sclerosis (ALS) patients with the misfolded SOD1 protein.

EuroBiotech Report—The U.K.'s R&D plan, Lundbeck, Genfit and AstraZeneca

In this week's EuroBiotech Report, UCB commits to U.K., and Lundbeck, Genfit and AstraZeneca post midphase data.

FiercePharmaAsia—Takeda-Shire finish line; Sun’s crisis; J&J-Legend CAR-T

The Takeda-Shire megamerger won go-aheads from shareholders; Sun Pharma plummets on reports of a potential government probe and governance issues; J&J and Legend update results from an early-stage myeloma trial testing their much-hyped CAR-T therapy; and more.

Chutes & Ladders—Xenotransplantation firm eGenesis hires new R&D head

Xenotransplantation firm eGenesis hired Wes Westlin as its R&D head; Relay added executives to its chemistry and R&D teams for its transition to development stage; and Navidea bought aboard a new CMO focused on imaging biomarkers. Those moves plus more hirings, firings and retirings throughout the industry.

Resources

[Whitepaper] Evaluating RIM Suites? Unification matters.

Learn how to spot an imposter with an integrated suite vs. one that’s unified. Read this whitepaper to learn more.

[Whitepaper] In-House Versus Outsource: A Decision-Making Guide

Read this whitepaper to learn how the biologics market is quickly evolving and how these changes pose several risks to a molecule’s success.

[Webinar] Becton Dickinson’s Digital P2P Solution Simplifies Spend Management

Learn how Becton Dickinson implemented Coupa to create an easy-to-use purchase to pay process that increased efficiency across the organization.

[Whitepaper] Evaluation of the claraT Total mRNA report in an RNA- Sequencing dataset from malignant melanoma cancer patients treated with Ipilimumab

Download the whitepaper to learn more.

[Whitepaper] Putting the Researcher in the Driver’s Seat

Learn how to fast-track your research workflows!

[Report] Clinical Operations Report: Learn the Top Industrywide Priorities

Industry Research: Read the 2018 Unified Clinical Operations Report to find out how pharmas and CROs are evolving clinical trial processes.

[Webinar] QSP Approaches to Determine Best in Class Properties for Targeted Anabolic Growth Factor to Arthritic Joints

This on-demand webinar introduces a quantitative systems pharmacology (QSP) model of targeted anabolic growth factors for intra-articular injection for the treatment of diseased joints.

[Research Report] Challenges And Opportunities In Clinical Data Management

New research reveals more than 50% of clinical data management professionals surveyed, are not confident in the quality and completeness of their clinical trial data.

[Whitepaper] Migraine Treatment and Calcitonin Gene-Related Peptide Inhibitors: Real-World EHR Case Study

New Case Study – Leveraging Real-World Evidence From EHR to Assess Migraine Management

[Whitepaper] The Future of Cell & Gene Therapy

What does data tell us about the future of cell & gene therapy?

[Whitepaper] Why Life Sciences Companies Leverage Managed Regulated Infrastructures

Outer Edge Technology specializes in designing and managing regulated cloud-based infrastructures for the Life Sciences Industry – typically leveraging the AWS and Microsoft Azure platforms.

[eBook] 2018 Weekly Compendium

The Biopharma industry is moving at lightning speed and it can be a challenge to keep pace. Here at Biotech Primer we spend hours each week researching, writing, and editing original content for the Biotech Primer WEEKLY with one goal in mind: to help everyone better understand the latest science and technology driving today’s healthcare industry.

Events