Arbor, on a roll, nabs major $215M funding round
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Today's Rundown

Featured Story

Seeking an edge over Amgen, Mirati advances lower KRAS dose in Keytruda combo to improve tolerability

Mirati Therapeutics is looking to a KRAS-Keytruda combination to give it an edge over Amgen in lung cancer. After lowering the dose of its KRAS drug, Mirati saw around 60% of first-line patients respond to the combination—and lessened the tolerability concerns that initially held back the cocktail.  

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Top Stories

Novartis dumps 2nd bispecific from $2.6B Xencor pact, dealing further blow to hopes for blood cancer target

Novartis has hacked off another piece of its $2.6 billion deal with Xencor, terminating its rights to a CD123xCD3 blood cancer bispecific that had a troubled time in early clinical development.

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Arbor's autumn: A $1.2B Vertex pact, now a $215M series B for liver, CNS diseases

Just three months after a $1.2 billion pact with Vertex, Arbor Biotechnologies has hauled in $215 million in a series B to bankroll its work in gene editing tech. The round includes financing from Vertex, Temasek, Ally Bridge Group and TCG Crossover.

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Sponsored: A New Reference Model for Clinical Trial Recruitment, Enrollment and Retention Success

Rare diseases demand a modern recruitment approach grounded in uncovering the ideal, medically-eligible patient population with the highest propensity for study enrollment and retention.

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He got the first postpartum depression drug to market. Now, ex-Sage CMO takes helm at Ancora to revive a Taisho drug

In its quest to revive a failed Taisho depression drug, Ancora Bio needed a leader with experience getting a therapy to market for the depression field. So, the Joe Jimenez-founded biotech has snagged Sage CMO Stephen Kanes, who secured the first FDA approval for a postpartum depression drug.

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OcuTerra snags $35M for phase 2 trial of eye drop with former Allergan CEO as chair

After rebranding from SciFluor Life Sciences and adding Centrexion co-founder Kerrie Brady as CEO last year, OcuTerra Therapeutics is ready for its next phase. The biotech secured $35 million to bankroll a phase 2 trial of its single asset.

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Flagship unveils its next RNA bet with $50M for Alltrna to explore thousands of genetic diseases using transfer RNA

Flagship helped lead the way in messenger RNA by incubating Moderna. Now, the biotech founder wants to revolutionize transfer RNAs with $50 million dedicated to Flagship's newest venture, Alltrna.

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Alcon scopes out $475M acquisition of glaucoma stent maker Ivantis

Three years after Alcon pulled its CyPass Micro-Stent from the market due to safety concerns, the Novartis spinoff has found another glaucoma treatment device to take its place.

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Drugmakers get mixed bag in lawsuit rulings over 340B contract pharmacy moves

Drugmakers got mixed results in two legal rulings on their ability to restrict sales of drugs discounted under the 340B program to contract pharmacies.

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Bristol Myers Squibb's Opdivo posts another win in early lung cancer, but debate over treatment approach likely remains

Bristol Myers Squibb has expanded Opdivo’s first-in-class win in pre-surgery non-small cell lung cancer, teeing up a potential FDA filing. Opdivo added to neoadjuvant chemotherapy before surgery improved event-free survival in early lung cancer, the company said.

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Resources

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Whitepaper: Formulation Strategies When Transitioning From Vial to PFS

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Whitepaper: How the Chronic Insomnia Market Raises Big Questions About Digital Therapeutics

Paper describing how the chronic insomnia market offers big lessons for any biopharma company thinking about getting into digital therapeutics in any therapeutic area.

Whitepaper: Create a seamless experience across eConsent, eCOA & more

Find out how to improve clinical protocol adherence, and thus patient outcomes, by 15%+ with Medable’s latest White Paper.

Whitepaper: A Checklist for eCOA Solution Deployment

Every detail is important when selecting a new eCOA solution; learn more about the current eCOA landscape, best practices, and crucial considerations for successful eCOA solution deployment in this white paper.

2021 Report: Clinical Trial Management in a Post-Pandemic World

New market research provides valuable insight into the impact of adaptations made in clinical trials during the pandemic.

Whitepaper: Enhance the cost-effectiveness of your cGMP chemical supply chain

Learn how to develop a high-performing supply chain for cGMP chemicals used throughout your biologics workflow. Download the free whitepaper from Thermo Fisher Scientific

Paid Marketplace: Online Graduate Programs Designed for Your Career

Drexel University’s online graduate programs in biomedicine, clinical research, drug discovery, and molecular medicine were developed with working professionals in mind, providing you with the education, practical skills, and competitive edge you need to be successful in your career. Learn more.

eBook: Get solutions to market faster

Read Get to Know Cloud Content Management for Life Sciences and learn how to eliminate silos across all workflows, from R&D to commercialization.

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