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November 03, 2016

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Today's Rundown

  1. Merck posts package of BACE1 data from Alzheimer’s trials

  2. Blood clots hit Roche hemophilia trial

  3. Midstage Vitae drug flops in PhII, leaving Allergan’s $640M buyout in question

  4. Boehringer backs $20M round in ADC cancer player

  5. Brad Thompson exits Oncolytics Biotech

  6. From FierceCRO: QuintilesIMS announces new biz segments, share repurchase program

  7. From FiercePharmaMarketing: Why is Valeant's 'blockbuster' libido drug Addyi a dud? Shoddy marketing, investor lawsuit claims

Featured Story

Merck posts package of BACE1 data from Alzheimer’s trials

Merck has posted a roundup of data generated to date on its BACE1 inhibitor in Alzheimer’s disease tests and trials. The package includes results from a seven-day, 32-person trial that linked the drug to lower levels of beta-amyloid peptide 40 and other biomarkers of Alzheimer’s.


Top Stories

Blood clots hit Roche hemophilia trial

Just a few months after Roche posted what it deemed a “promising safety and efficacy profile” from a long-term test of its experimental hemophilia med, the Swiss major is now said to have suffered a setback after a number of patients had blood clots.

Midstage Vitae drug flops in PhII, leaving Allergan’s $640M buyout in question

Allergan took an R&D hit this quarter as it emerged from analysts that a Phase II test of dermatology med VTP-38543, acquired as part of a $640 million buyout deal of Vitae in September, has failed.

Boehringer backs $20M round in ADC cancer player

NBE Therapeutics has raised CHF 20 million from investors including PPF Group and Boehringer Ingelheim Venture Fund. The antibody-drug conjugate (ADC) specialist will use the Series B to move its lead candidate through a Phase I/II trial.

Brad Thompson exits Oncolytics Biotech

Canadian cancer biotech Oncolytics announced alongside its financials that its long-standing president and CEO, Brad Thompson, will be leaving the company “immediately.”

QuintilesIMS announces new biz segments, share repurchase program

In its first quarter after the merger of Quintiles and IMS Health, the newly formed single company said it has kick-started a $1.5 billion repurchase of QuintilesIMS' outstanding common stock as it also forms new business units.

Why is Valeant's 'blockbuster' libido drug Addyi a dud? Shoddy marketing, investor lawsuit claims

When Valeant bought Sprout and its controversial female libido drug Addyi, it agreed to a marketing blitz that would deliver royalties to Sprout's former shareholders. Valeant bungled the job, those former investors say. And they’re taking their gripes to court.

News of Note

EnBiotix has completed the asset buyout of AMP Therapeutics, an antimicrobial peptide portfolio company from both Novartis and Boehringer’s venture arms. Release

A new report by a former health minister in the U.K. says a ‘hard Brexit’ could delay new meds getting to patients. Story

Acadia Pharmaceuticals has started a new Phase III test for its med pimavanserin as an adjunctive therapy for schizophrenia in patients who don’t respond well with current antipsychotics. Statement

 

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