| | Taking the Fight to Rare Cancers Beating rare cancers demands expertise in oncology and rare diseases. Our white paper shows how adaptive design, study committees, and cross-industry cooperation are fueling real progress. Premier Research. Built for Biotech℠ |
Today's Rundown Amgen KRAS colon cancer data disappoint Gene-editing Beam Therapeutics sets sights on $100M IPO AbbVie's PARP inhibitor veliparib finally gets a win, but can it compete? [Sponsored] Boost clinical supply chain performance using digital technologies Novartis chalks up another phase 3 asthma win as approval nears Astellas, Seattle Genetics' Keytruda combo shrinks 71% of bladder cancers G1 shares data on significant increase in breast cancer survival Lilly's RET drug shrinks more than half of rare thyroid cancers Will Adaptimmune's SPEAR-T results in a rare sarcoma appease investors? Eyeing Novartis and Pfizer, Chi-Med touts neuroendocrine cancer win Featured Story | | | Saturday, September 28, 2019 In lung cancer, Amgen’s buzzy KRAS drug hit the heights. But in its latest update, it didn't follow suit in colon cancer. Amgen was testing its drug in an early-stage, phase 1 focused on patients with previously treated KRAS G12C-mutant solid tumors. |
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Top Stories Friday, September 27, 2019 Beam Therapeutics is hitting Wall Street. Nearly seven months after topping up its coffers with a $135 million series B round, the company filed Friday to raise up to $100 million in its Nasdaq IPO. Sunday, September 29, 2019 BARCELONA—Quietly, and without the fanfare of gene and cell therapies, PARP inhibitors from the likes of AstraZeneca, Merck and GlaxoSmithKline/Tesaro have been racking up big trial wins in breast and ovarian cancers. Monday, September 30, 2019 Personalized medicine, greater drug portfolio complexity, and quicker clinical development is raising the stakes. How can digital provide a boost in clinical supply chain performance? Monday, September 30, 2019 A phase 3 trial of Novartis’ QMF149 in patients with uncontrolled asthma has met its primary endpoint. Novartis showed the drug combination is better at improving lung function than an inhaled corticosteroid alone. Saturday, September 28, 2019 Astellas and Seattle Genetics’ antibody-drug conjugate is at it again. On Saturday, the duo revealed data showing enfortumab vedotin paired with Merck’s Keytruda shrank 71% of tumors and wiped out 13% of them in previously untreated patients with advanced urothelial cancer Saturday, September 28, 2019 G1 Therapeutics has linked the addition of trilaciclib to chemotherapy to improved overall survival in triple-negative breast cancer patients. People who received the CDK4/6 inhibitor lived 20.1 months, on average. Sunday, September 29, 2019 The RET inhibitor Eli Lilly picked up in its Loxo Oncology buyout continues to deliver. On the heels of an encouraging performance in lung cancer, the drug shrank tumors in more than half of patients with a rare thyroid cancer who had already tried at least two kinase inhibitors. Monday, September 30, 2019 Adaptimmune’s shares have dropped 70% this year amid disappointing data for the company’s SPEAR-T cells to treat solid tumors. Now, the company is rolling out phase 1 data for its lead product it hopes will accelerate it toward commercialization. Monday, September 30, 2019 Pfizer’s Sutent and Novartis’ Afinitor and Lutathera are all approved to tackle certain neuroendocrine tumors, but no one drug covers all types of them. Chi-Med is hoping to change that—and now it has a late-stage clinical win under its belt. | | Congratulations to the Fierce 15 You have proven that great innovations are created with breakthrough science, insightful leaders and unwavering resolve. Thank you. And we look forward to helping you advance to your next milestone. |
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