Today's Rundown NuCana's retooled chemo drug comes up short in pancreatic cancer phase 3 Chasing Astellas and Mitsubishi, GSK files for Japanese approval of oral anemia drug Oncorus raises $80M for 2-front oncolytic virus R&D push Y Combinator startup pursuing 'scarless' pouch for cell transplants in diabetes Pfizer adds $500M to gene therapy manufacturing plant where it will hire 300 workers Featured Story | | | Wednesday, August 21, 2019 A phase 3 study of NuCana’s lead drug, a reformulated version of Eli Lilly’s Gemzar, was halted because it is unlikely to succeed. A data-monitoring committee decided it was doubtful the new version would beat the chemotherapy veteran. |
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Top Stories Wednesday, August 21, 2019 GlaxoSmithKline has filed for approval of renal anemia drug daprodustat in Japan. The filing follows data from Japanese phase 3 trials that assessed the oral hypoxia-inducible factor prolyl hydroxylase inhibitor in chronic kidney disease patients. Wednesday, August 21, 2019 Oncorus has raised $79.5 million to advance oncolytic viruses. The series B round equips Oncorus to move its lead prospect into the clinic and nominate an intravenously administered viral candidate early next year. Tuesday, August 20, 2019 Encellin is working on a cell pouch that cuts down on the disruptive scarring that comes with encapsulated cell transplants and eliminates the need for anti-rejection drugs. It hopes to test an insulin-producing cell transplant in humans next year. Wednesday, August 21, 2019 Pfizer is running behind in the race for a gene therapy and is shifting its production efforts into overdrive. The company will inject another $500 million into a gene therapy manufacturing plant and says it will hire another 300 workers. Resources Sponsored by: Alexander Group From sales headcount and budgets to new product launches and saying “yes” to millennials, hear the top 7 topics that are trending in sales compensation. Sponsored by: Wesco Pharmaceutical Solutions and WBR Insights The regulations and managing processes for hazardous, controlled and rare chemicals and biologics necessary for drug discovery are a huge distraction for R&D labs. Learn from the perspectives of industry executives the pain points and improvements they want in their processes for chemicals and biologics in pharmaceuticals R&D. Sponsored by: Kinaxis Download this life sciences industry spotlight to discover how concurrent planning can help you overcome complex supply chain challenges to drive down costs and improve efficiency. Sponsored by: Patheon, by Thermo Fisher Scientific Patheon, part of Thermo Fisher Scientific, offers advanced API manufacturing technologies such as continuous processing and continuous analytics to deliver high-quality products with well-defined features to meet your timelines and volume requirements. Sponsored by: ICON Understanding the challenges for formulary decision makers and manufacturers. Sponsored by: Veeva This white paper details how leveraging new reporting capabilities, live UAT feedback sessions, and an agile design approach to study builds will save them time and money. Sponsored by: BBK Worldwide The Study Voices survey challenges the myth that physicians won’t refer patients to clinical trials, and it identifies opportunities to engage physicians as partners in the enrollment process. Sponsored by: Catalent Download the case study to learn about the clinical supply management tools that helped a small sized pharma company during phase III of a multi-arm oncology study. Sponsored by: Catalent Watch a short video on demand led supply model. It is designed to meet the needs of patients, clinical sites, clinical team and sponsors and results in shorter lead time, less waste, less stock out risk and no booklet labels. Sponsored by: Catalent Download the eBook to explore a proactive approach for clinical supply management. Latin America Healthcare Compliance Certificate Program September 23-26, 2019 BioBasics: Biotech For The Non-Scientist Oct 22-23, 2019 | San Diego, CA BioImmersion: Biotech for the Non-Scientist October 23-25, 2019 | Chicago, IL 4th FierceBiotech Drug Development Forum October 28-29, 2019 | Boston, MA Drug Development Boot Camp® 2019 November 20-21, 2019 | Boston, MA | Register NOW and start Pre-Boot Camp Preparation! | 