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June 07, 2019___

Today's Rundown

Featured Story

Vertex makes $420M preclinical play for DMD gene editing field

Vertex is paying $420 million upfront to go after the muscular dystrophy market. The outlay will give Vertex ownership of Exonics and expand its deal with CRISPR Therapeutics, setting it up to use gene editing to treat Duchenne muscular dystrophy and myotonic dystrophy type 1. 

Thank you to Lonza for sponsoring this week's coverage of BIO.

Top Stories

Grail finds a new CEO in former Juno chief Hans Bishop

Just weeks after securing a breakthrough designation, honing its cancer detection strategy and presenting promising early results, Grail is bringing on a new CEO as it inches its blood test toward the market. Former Juno Therapeutics helmsman Hans Bishop will pick up Grail’s quest to develop a simple, pan-cancer liquid biopsy.

BIO: In conversation with Emil Kakkis, Ultragenyx CEO

PHILADELPHIA—When Emil Kakkis started Ultragenyx in 2010, it was a company of two. Nine years later, Kakkis reflected on how he’s preserved the culture of a small biotech even as the rare disease company expands beyond 700 staffers.

[Sponsored] How to Make the Most of Your Clinical Trial Data—All of it

Pharma and biopharma have endless data at their disposal. Why aren't they using it? Here's how to make the most of your data for clinical success.

BIO: In conversation with Helen Torley, CEO of Halozyme

Halozyme CEO Helen Torley discusses the company’s two-pronged strategy, what’s up next for the company and why biotechs are filing IPOs earlier and earlier.

BIO: Meet Refuge Biotech, the company developing ‘intelligent’ cell therapies

Refuge is working on “intelligent” T cell therapies that can “think for themselves and react to their environment." Its lead candidate is a HER2-based treatment for solid cancers, an arena in which T cell therapies have seen limited success.

Headed for the exit: Sanofi CEO Brandicourt to retire, Novartis' Hudson steps in

Sanofi CEO Olivier Brandicourt has worked to reshape the drugmaker during his four-plus years at the company, but problems remain. Brandicourt is now retiring, and Novartis' Paul Hudson will take the job.

EuroBiotech Report—Woodford's woes, Bayer-Arvinas, AstraZeneca, Sanofi and Novartis

In this week's EuroBiotech Report, Woodford suspends flagship fund, Bayer inks protein degradation deal and AstraZeneca talks up approach to cancer.

FiercePharmaAsia—China audits for Big Pharma; Takeda's phase 3 trial failure

Eli Lilly and other multinational drugmakers will be audited in China. Plus, Takeda entered an R&D collab and disclosed a trial failure. And more.

Chutes & Ladders—Bristol-Myers unveils post-Celgene R&D team

Bristol-Myers unveils team to lead R&D after Celgene deal closes; GE Healthcare executive to lead dermatology biotech LEO Pharma; and after 31 years at Merck, Schechter jumps for LabCorp CEO job. Those moves plus more hirings, firings and retirings throughout the industry.

Resources

[POCKET GUIDE] Reference and Literature Management Made Easy

Get 5 quick tips for faster research and better results!

[Report] Precision medicine from concept to clinic

In this publication, Blue Latitude Health maps the journey of stakeholders impacted by the rise of precision medicine today. Download the report.

[Whitepaper] Flow Chemistry: A Scale-Up Solution for Modern API Development & Manufacturing

Increase Safety & Flexibility with Flow Chemistry

[On-Demand Webinar] Lessons Learned Implementing an End-to-End RIM Solution

IONIS shares best practices for implementing an end-to-end RIM solution in this on-demand webinar. Watch now.

[Whitepaper] Site-specific, Patient-centered and Whip-smart: Enrollment Assistants Adapt to a Shifting Landscape

Increasingly complex clinical trials place a tremendous burden on study sites, exacerbating already-troubling recruitment and enrollment issues. Overwhelmed, many sites may not be up to the task or have the appropriate infrastructure, creating costly delays that keep new therapies from patients.

[Case Study] Clinical Supply Management

Download the case study to learn about the clinical supply management tools that helped a small sized pharma company during phase III of a multi-arm oncology study.

[Video] Demand Led Services and Clinical Supply Efficiency

Watch a short video on demand led supply model. It is designed to meet the needs of patients, clinical sites, clinical team and sponsors and results in shorter lead time, less waste, less stock out risk and no booklet labels.

[eBook] Strategies for Efficient Clinical Supply Management and Forecasting

Download the eBook to explore a proactive approach for clinical supply management.

[Executive Summary] Achieving a Successful Drug Product Tech Transfer

Download the executive summary to learn key considerations for a successful technology transfer for manufacturing drug products, including a case study on overcoming challenges in a process transfer for a sterile diluent.

[Whitepaper] Choosing the Best Sterile Dosage Form for Phase I Clinical Supply Needs

Choosing the Best Sterile Dosage Form for Your Phase I Clinical Supply Needs.

[Whitepaper] Delivering oral solid dose product to Phase I Clinic in 14 weeks

Designed with speed & flexibility,Quick to Clinic™ for Oral Solid Dose helps deliver products to Phase I Clinic in as little as 14 weeks.

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