'Provocative' bispecific data prompt a close look by Lilly, Novartis

Today’s Big News

Jun 5, 2025

Chasing Sarepta, RegenXBio links DMD gene therapy to improved outcomes


Cullinan pens $700M pact for BCMA bispecific to pair with another autoimmune T-cell engager


With BMS and Pfizer joining the PD-1 bispecific race, Lilly and Novartis size up the hot cancer field


Corcept unveils promising survival data from failed phase 2 ALS trial


Rapt Therapeutics cuts staff for 2nd time in less than a year, continuing fallout from FDA hold


Seyltx reserves option to boost chronic cough pipeline with 8 GluN2B antagonists


Fierce Biotech Fundraising Tracker '25: Allay accesses $57M series D; SpyGlass secures $75M series D

The Top Line Podcast: Don’t miss out on the newest episode. Listen now.

 

Featured

Chasing Sarepta, RegenXBio links DMD gene therapy to improved outcomes

RegenXBio has shared updated phase 1/2 data on its Duchenne muscular dystrophy (DMD) gene therapy, providing evidence that its pivotal dose improves functional outcomes in older boys with the disease.
 

Top Stories

Cullinan pens $700M pact for BCMA bispecific to pair with another autoimmune T-cell engager

Cullinan Therapeutics is paying $20 million upfront for a BCMAxCD3 bispecific T-cell engager that the biotech plans to pair with its existing CD19 candidate.

With BMS and Pfizer joining the PD-1 bispecific race, Lilly and Novartis size up the hot cancer field

As Merck & Co., Bristol Myers Squibb and Pfizer have hopped on the PD-(L)1xVEGF bispecific bandwagon, the question becomes how far the fanfare will spread.

Precision medicine’s next frontier: unlocking the power of biospecimens

Austin Read of Thermo Fisher Scientific discusses how combining biospecimens with real-world data is advancing diagnostics, treatment and the future of patient care.

Corcept unveils promising survival data from failed phase 2 ALS trial

Corcept Therapeutics has tried to cast its recent phase 2 amyotrophic lateral sclerosis (ALS) failure in a more flattering light by pointing to promising survival data.

Forging the future of cell therapy: Bayer and BlueRock’s unique journey

Discover how Bayer and BlueRock are redefining biotech partnerships. From breakthrough Parkinson’s therapies to a unique “arm’s-length” model, this episode of The Top Line dives into what makes their collaboration a blueprint for the future.

Rapt Therapeutics cuts staff for 2nd time in less than a year, continuing fallout from FDA hold

Rapt Therapeutics has conducted its second round of layoffs in just under a year, continuing a period of upheaval following the clinical hold—and eventual discontinuation—of the immunology biotech’s former lead asset.

Delivering the Future of Radiopharmaceuticals with Precision

Radiopharma is revolutionizing modern medicine. Discover how precision logistics empowers faster, safer delivery of life-impacting therapies when every second counts.

Seyltx reserves option to boost chronic cough pipeline with 8 GluN2B antagonists

Cough-focused biotech Seyltx has secured the option to license a portfolio of eight GluN2B antagonists from NeurOp, including one candidate that has completed a phase 1 trial.

Fierce Biotech Fundraising Tracker '25: Allay accesses $57M series D; SpyGlass secures $75M series D

The Fierce Biotech Fundraising Tracker records venture capital rounds of $50 million or more secured by biotechs.

Bayer gains key FDA expansion for fast-rising prostate cancer drug Nubeqa

Bayer has taken another step toward achieving its €3 billion peak sales estimate for androgen receptor inhibitor Nubeqa, scoring an FDA approval to expand its use to all patients with metastatic castration-sensitive prostate cancer, with or without added chemotherapy.

UnitedHealth posts shareholder FAQ that offers greater detail on C-suite strategy

UnitedHealth Group hosted a shareholder meeting earlier this week amid a series of financial challenges and negative headlines, and a FAQ document posted to its website Wednesday offers a look at the questioning that executives were bracing for.
 
Fierce podcasts

Don’t miss an episode

What’s next for tech-enabled home care? A look at the policy road ahead

This week on "Podnosis," we’re examining the future of tech-enabled home care and the policy decisions that could determine whether these models become permanent fixtures in the U.S. healthcare system.
 

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Building Peak Performance Go-to-Market Operations

We analyzed ~300 launches to identify the factors most correlated with commercial success & built a framework for peak go-to-market performance.
 

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