Today's Rundown Gilead shows durability of filgotinib ahead of face-off with AbbVie Safety issues for Pfizer's Dupixent rival may 'give prescribers pause' GSK's cell therapy R&D lead jumps ship to partner Immatics Accent, AstraZeneca take aim at RNA modifiers in $55M cancer pact Pfizer, Merck, AZ, J&J and Moderna selected as 'Warp Speed' finalists: NYT Spectrum Pharma nabs Five Prime, Gilead veteran as new clinical lead Athira reels in $85M for phase 2/3 Alzheimer's study Daiichi Sankyo taps CRO Syneos Health to help run ADC cancer drug work, including Enhertu Gene-edited T cells to treat diabetes inch closer to clinical trials Featured Story | | | Thursday, June 4, 2020 Gilead and Galapagos have released 52-week clinical trial data showing the durability of filgotinib in rheumatoid arthritis patients. The update comes as the partners close in on a FDA approval that will position them to compete with rival JAK inhibitors sold by AbbVie, Eli Lilly and Pfizer. |
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Top Stories Thursday, June 4, 2020 Pfizer’s eczema hopeful has posted promising efficacy results from multiple phase 3 studies, building its case to challenge Sanofi and Regeneron’s Dupixent. But there’s a little something that could stand in its way: safety. New data show that patients taking abrocitinib had reductions in platelet counts, as well as a higher risk of serious infection. Thursday, June 4, 2020 Just a few months after GlaxoSmithKline penned a $50 million deal with biotech Immatics for its T-cell work, the executive running the Big Pharma’s cancer cell therapy unit is upping sticks to join the U.S.-European startup. Thursday, June 4, 2020 Since it launched in 2018, Accent Therapeutics has busied itself discovering new targets for cancer drugs in the space of RNA-modifying proteins. But the time for lying low is over—just weeks after the biotech raised a $63 million round, it’s striking its first Big Pharma partnership with AstraZeneca. Wednesday, June 3, 2020 The Trump administration has selected its COVID-19 vaccine finalists for Operation Warp Speed, which aims to deliver safe and effective coronavirus vaccines to Americans by the end of the year, The New York Times reports. Thursday, June 4, 2020 After swinging the ax on staffers last year and gaining a new CEO a few months back, Five Prime Therapeutics’ clinical development lead is hoping for a more stable time at new employer Spectrum Pharma. Thursday, June 4, 2020 Athira Pharma changed its name last year to reflect its focus on regenerative medicine. Now, it’s snagged $85 million to advance those medicines, which includes bankrolling a phase 2/3 trial in Alzheimer’s for its lead asset, designed to restore the lost neural connections in the brain or spur the growth of new ones. Thursday, June 4, 2020 Japanese pharma company Daiichi has penned a new deal with Syneos Health to launch a “coalition” that sees the CRO work on its big-name antibody-drug conjugate targets. Wednesday, June 3, 2020 Scientists at Seattle Children’s Research Institute and the Benaroya Research Institute have engineered T cells that mimic the immunosuppressive properties of regulatory T cells—an approach that they say could potentially be used to treat autoimmune diseases such as Type 1 diabetes. | | LabConnect is now offering global analytical and operational services to meet your COVID-19 testing requirements. We offer viral load testing by RT-qPCR and multiple COVID-19 screening assays. Connect with LabConnect today. We are here to help. |
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Resources Sponsored by: Blue Matter, strategic consultants in the life sciences White paper describing 7 keys to success for any biopharma company that is entering (or thinking about entering) Europe. Sponsored by: Clinical Ink This white paper covers a Phase III case study; BYOD advantages and misconceptions; and regulatory, copyright, and equivalency considerations. Sponsored by: Clinical Ink Learn how GI specific data capture solutions can support virtual and hybrid trials during COVID-19. Sponsored by: Copyright Clearance Center Dive into the history of biomedical classification and how these systems have evolved to address new technology and use cases. Sponsored by: Catalent Learn about a real-world example of how clinical supply management expertise was applied to overcome inventory challenges for a complex, global study. Sponsored by: Catalent Whether a study is simple or highly complex, forecasting and simulation reports serve as data driven communication tools to help minimize risks and keep the study on track. Learn more about forecasting solutions for informed decision making and supporting contingency planning for clinical study. Sponsored by: Catalent Learn how to drive excellence within the forecasting process and utilize forecasting throughout the clinical study to better plan clinical supply budgets and project timelines. Explore how to identify potential supply-related issues before they can negatively impact your study. Sponsored by: Frontage Laboratories, Inc. Listen to our brand-new Frontage Laboratories podcast where you’ll take home tips for developing residual host cell proteins ELISA assay for biopharmaceutical products using commercial kits. Wednesday, May 20, 2020 | Time: 10am-3.30pm (BST) Join us for a day of discovery as global experts in Cardiology, Pharmacology and Diabetes discuss state of the art methods in early phase clinical research. Sponsored by: Oracle Health Sciences Patient-facing digital technologies are playing an important role in clinical trials for new drugs and medical devices, to the point where conducting virtual trials is becoming mainstream. But terms like remote trials, direct-to-patient trials, hybrid trials, decentralized trials, and more all add to the confusion of what makes a trial "virtual." Sponsored by: Outer Edge Technology Covid-19 has forever changed the paradigm of “go to the office” business operations. Learn how an effective Cloud Strategy can position your company for success in these unprecedented times. Sponsored by: Cenduit, LLC Download this case study to read about how Cenduit navigated these challenges, and successfully supports the trial sponsor to execute the umbrella trial with agility. Sponsored by: Acorn AI by Medidata, a Dassault Systèmes company Case Study: Oncology-focused pharmaceutical company strengthens product launch by identifying hundreds of high-value physicians with Acorn AI. Sponsored by: Clarify Health Pharma launch teams spend significant resources on data and analytics with limited ROI. Read this case study to learn how a Life Sciences company identified two times more patients best suited for therapy, using Clarify’s deep and longitudinal patient and HCP insights. Medical Affairs Strategic Summit (MASS) East April 14-16, 2020 | New Brunswick, NJ PEGS Virtual Interactive Summit Virtual Event | June 2-26, 2020 European Healthcare Compliance Certificate Program June 2-5, 2020 | Paris, France BIO 2020 Now Fully Virtual: Announcing BIO Digital June 8-11, 2020 | Virtual Event Drug Development Boot Camp® 2020 November 18-19, 2020 | Register now! Pre-Boot Camp training is in session. | Take your new medicine development skills to the next level. | 