ADC Tx axes sole clinical-stage candidate after seeing ph. 1 data

Today’s Big News

May 14, 2025

GSK pays $1.2B upfront for Boston Pharmaceuticals' lead liver disease drug


Novo Nordisk inks $2.2B deal for Septerna's preclinical obesity programs


AbbVie pays ADARx $335M cash for next-gen siRNA options


ADC Therapeutics drops only clinical-stage drug after reviewing phase 1 leukemia data


Allogene lays off 28% of staff to extend runway amid delays to CAR-T updates


Kyverna lays off 16% of staff as autoimmune CAR-T plans pick up pace


Alumis' Acelyrin merger back on track after shareholders unswayed by activist investor


Arcturus stops work on early-stage vaccine programs in effort to 'streamline resources'

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Featured

GSK pays $1.2B upfront for Boston Pharmaceuticals' lead liver disease drug

GSK is brushing off dropping a cancer asset on Tuesday by snagging a late-stage liver disease drug for a hefty $1.2 billion upfront.
 

Top Stories

Novo Nordisk inks $2.2B deal for Septerna's preclinical obesity programs

Novo Nordisk is making yet another bet on obesity, offering Septerna more than $200 million in upfront and near-term payments for rights to preclinical oral small molecules that hit targets including GLP-1.

AbbVie pays ADARx $335M cash for next-gen siRNA options

AbbVie is paying ADARx Pharmaceuticals $335 million upfront to secure options on next-gen small interfering RNA therapeutics across several disease areas.

Medrio CEO on building stability and innovation in clinical trials

Medrio CEO Nicole Latimer discusses strategiesthe company’s mission to streamline clinical trials, embrace meaningful innovation and support life sciences organizations from startup to FDA approval.

ADC Therapeutics drops only clinical-stage drug after reviewing phase 1 leukemia data

Zynlonta manufacturer ADC Therapeutics is continuing to prune its pipeline, calling time on its sole remaining clinical-stage candidate after taking a look at the early-stage data.

Allogene lays off 28% of staff to extend runway amid delays to CAR-T updates

Allogene Therapeutics is cutting back to stretch its cash runway into the second half of 2027, laying off 28% of its workforce and focusing its resources on getting two clinical programs to inflection points. The off-the-shelf CAR-T cell therapy specialist disclosed the changes alongside delays to two milestones.

Kyverna lays off 16% of staff as autoimmune CAR-T plans pick up pace

Kyverna Therapeutics may consider it had an “exceptional start to the year,” but that didn’t immunize the cell therapy biotech from the wider industry trend of layoffs.

Alumis' Acelyrin merger back on track after shareholders unswayed by activist investor

Acelyrin’s shareholders have decided to power ahead with a planned merger with immune-mediated disease specialist Alumis despite the best efforts of an activist investor to derail the deal.

Arcturus stops work on early-stage vaccine programs in effort to 'streamline resources'

San Diego-based RNA biotech Arcturus is doubling down on mRNA therapeutics and stepping back from earlier-stage vaccine work in an effort to prioritize spending and extend its cash runway.

Trump administration axes $450M more in grant funding to Harvard

The federal government is slashing $450 million in grant funding to Harvard University, adding on to the $2.2 billion that has already been cut, according to a May 13 statement from the Joint Task Force to Combat Anti-Semitism.

Roche to spend $550M building Indianapolis HQ into CGM production hub

The announcement follows a five-year, $50 billion commitment from the Swiss pharma to expand its U.S. footprints in R&D and production.

Protests disrupt Medicaid markup hearing as trade and advocacy groups descend on DC

It's markup week in the House for the 'one big, beautiful bill.' Lawmakers are debating significant programmatic changes to Medicaid as advocacy groups push back on Republicans' plans.

As Bayer's restructuring rolls on, Kerendia and Nubeqa power pharma unit to surprising sales increase

Thanks to hefty sales increases from kidney disease drug Kerendia and prostate cancer treatment Nubeqa, Bayer’s pharma division weathered the storm from the loss of exclusivity in the U.S. of blockbuster Xarelto in the first quarter.

Disease prevention orgs ramp up pressure on Kennedy ahead of Congressional hearings

Secretary Robert F. Kennedy Jr. is defending the Trump administration's actions in reshaping the HHS. Industry pushback, and fear, is plaguing national healthcare organizations.
 
Fierce podcasts

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Angela Hwang on her pivot from Big Pharma to biotech

This week on "The Top Line," Angela Hwang reflects on her leap from nearly 30 years at Pfizer to leading a biotech startup—and the career lessons that continue to guide her leadership and commitment to developing diverse talent.
 

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Best Practice Medical Affairs Organization Study Report

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