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May 04, 2017

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Today's Rundown

  1. Swiss majors Roche and Novartis back gene therapy upstart

  2. Novartis adds to NASH pipeline, activating license for Conatus' emricasan

  3. Poxel shares jump 40% after diabetes trial hits primary goal

  4. [Sponsored] Mitotech’s SkQ1 targets mtROS, and a long list of age-related diseases

  5. I-O startup Gritstone lures Rousseau from Genentech

  6. Covance plans job cuts and lab shutdown from stagnant Q1 performance

  7. George Clinical buys up CRO unit from Vector Oncology, boosting its ops

  8. LivaNova snaps up Minnesota’s Caisson for $72M

  9. Pricing furor aside, drug spending growth slowed last year—but still hit $323B

Featured Story

Swiss majors Roche and Novartis back gene therapy upstart

Newly born European biotech Vivet Therapeutics has started life with €37.5 million ($41 million) and an executive team made up of Novartis, Sanofi and Gensight veterans, as the company looks to get to work on its gene therapies for a host of rare diseases.

Top Stories

Novartis adds to NASH pipeline, activating license for Conatus' emricasan

Novartis has bolstered its R&D portfolio for NASH, a progressive fatty liver disease tipped to become a $20 billion to $35 billion market in the coming years, with its second deal in a month.

Poxel shares jump 40% after diabetes trial hits primary goal

A phase 2b trial of Poxel’s Type 2 diabetes candidate imeglimin has met its primary endpoint. The data sent shares in Poxel soaring 40% and set the company up to push into a phase 3 trial before the end of the year.

[Sponsored] Mitotech’s SkQ1 targets mtROS, and a long list of age-related diseases

It’s a critical tradeoff for life. Our bodies use sugar and fat from the food we consume to produce energy in our cells’ mitochondria, the internal powerhouses that give us the energy we need for all our vital functions.

I-O startup Gritstone lures Rousseau from Genentech

Gritstone Oncology has appointed Raphaël Rousseau, M.D., Ph.D., as its CMO. Rousseau joins Gritstone from Genentech, becoming the latest biopharma veteran to join the ranks at the well-financed personalized cancer immunotherapy startup.

Covance plans job cuts and lab shutdown from stagnant Q1 performance

LabCorp is planning a rejig of its CRO business Covance, and the short-term plan includes letting go of a lab along with the employees stationed there.

George Clinical buys up CRO unit from Vector Oncology, boosting its operations

Asia-Pacific CRO George Clinical has topped up its cancer services and boosted its U.S. presence after acquiring Memphis, Tennessee-based Vector Oncology's CRO division.

LivaNova snaps up Minnesota’s Caisson for $72M

LivaNova, which specializes in neuromodulation, cardiac surgery and rhythm management, will acquire Caisson Interventional, a Minnesota-based heart valve maker, for $72 million.

Pricing furor aside, drug spending growth slowed last year—but still hit $323B

Despite what you may have heard about drug pricing and expenses getting out of hand, net spending growth actually fell in the U.S. last year. After discounts, pharmaceutical spending increased 4.8% in 2016, down from the 8.9% growth recorded in 2015.

News of Note

Regeneron's R&D costs were $507 million in the first quarter compared to $470 million a year ago, with the extra cash going on development work for fasinumab and REGN2810. Regeneron's financials

Rare disease biotech Rhythm has started a phase 3 test for setmelanotide, its first-in-class melanocortin-4 receptor, for an an ultrarare genetic disorder associated with severe, early-onset obesity and unrelenting appetite. Release

Former CDR Therapeutics and Xcyte Therapies executive Che-Leung Law, Ph.D., has become the new VP of translational medicine at T-cell biotech Harpoon. Statement

Resources

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[Whitepaper] Run the Trial You Want with Modern EDC

To thrive in a fiercely competitive market, life sciences companies need to set themselves apart by designing and executing the best trial and successfully deliver drugs to market first. Learn how a modern EDC can help.

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[Whitepaper] Immuno-Oncology and the Role of Biomarkers, Companion and Complementary Diagnostics

The recent evolution of immunotherapies and their potential applications have greatly impacted patients’ options for effective oncology treatments. These advances have been powered in part by the use of biomarkers, companion diagnostics (CDx) and complementary diagnostics. Read the white paper.

[Whitepaper] The Paperless Future of Healthcare and Life Sciences

DocuSign’s eSignature solutions modernize healthcare and life science organizations by eliminating paper and antiquated signature processes while meeting compliance requirements and reducing costs and errors.

[Whitepaper] DocuSign Life Sciences eBook: Reducing Cycle Time with Digital Transaction Management

The patients who rely on your scientific leadership are expecting more.

[Whitepaper] Streamline Regulatory Compliance in Life Sciences with Digital Transaction Management

The U.S. Department of Justice has collected upwards of $17 billion in settlements from the healthcare industry since 2009, including more than $2 billion from a single life sciences company.

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