Epsilogen buys TigaTx to combine immunoglobin expertise

Today’s Big News

Apr 7, 2025

GSK pens $2.5B pact for ABL Bio's tech to help antibodies bypass blood-brain barrier


Backing from BioNTech powers ADC specialist DualityBio toward $200M Hong Kong IPO


UK's Epsilogen acquires fellow immunoglobin biotech TigaTx to boost cancer antibody options


German research institute launches program to match threatened NIH grants with pharma funders


Lexeo locks in pivotal trial plan as clinical data pump up prospects of cardiac gene therapy


Trump administration faces mounting litigation as 16 states sue over NIH grant cuts


Relay Therapeutics starts third layoff wave in 1 year, shedding 70 staffers

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Featured

GSK pens $2.5B pact for ABL Bio's tech to help antibodies bypass blood-brain barrier

GSK has continued to flesh out its neuroscience strategy with a 2 billion pound sterling ($2.5 billion) deal to use a South Korean company’s tech to bypass the blood-brain barrier.
 

Top Stories

Backing from BioNTech powers ADC specialist DualityBio toward $200M Hong Kong IPO

Duality Biologics has begun offering stock, wading into a market routed by Trump’s tariffs in pursuit of up to 1.56 billion Hong Kong dollars ($200 million) to fund its antibody-drug conjugate pipeline. Backers including BioNTech have committed around one-third of the targeted IPO haul.

UK's Epsilogen acquires fellow immunoglobin biotech TigaTx to boost cancer antibody options

U.K.-based Epsilogen has bought Boston biotech TigaTx with the aim of creating “the world’s leading pan-isotype cancer antibody company.”

Project Optimus: Transforming Dose Optimization in Oncology Drug Development

Project Optimus is changing the landscape of oncology drug development by redefining dose optimization standards. Learn how sponsors can align with FDA expectations and implement more precise dose-finding strategies. Watch the full interview with Alex MacDonald now!

German research institute launches program to match threatened NIH grants with pharma funders

As scientists across the U.S. face increasing uncertainty due to funding freezes and mass layoffs at health agencies, German research institute BioMed X is stepping in to offer a lifeline. The institute has opened a matchmaking program to align threatened NIH grants with potential new funders from the pharmaceutical industry.

Lexeo locks in pivotal trial plan as clinical data pump up prospects of cardiac gene therapy

Lexeo Therapeutics has posted updated data in Friedreich ataxia patients, linking a gene therapy to improvements on outcomes the biotech plans to use as co-primary endpoints in a registrational trial.

Trump administration faces mounting litigation as 16 states sue over NIH grant cuts

Sixteen state attorneys general are suing the Department of Health and Human Services and the National Institutes of Health over research grant terminations. It's the second major lawsuit challenging the funding cancellations filed against the agencies this week.

Relay Therapeutics starts third layoff wave in 1 year, shedding 70 staffers

Relay Therapeutics has laid off about 70 employees, the biotech's third round of cuts in less than a year.

#FierceMadness: The Fonz leads Apellis’ Syfovre spot to victory in 2025 Drug Ad Tournament

Tapping into Henry Winkler’s status as a beloved Hollywood icon has majorly paid off for Apellis Pharmaceuticals, whose recent TV commercial for its geographic atrophy drug Syfovre starring the actor once known as Arthur Fonzarelli has been crowned the champion of this year’s Fierce Madness Drug Ad Tournament.

Brown University set to have $510M in federal research grants frozen: reports

Brown University has become the fifth university to be targeted by the Trump administration for funding cuts, according to reports, joining Ivy League peers Harvard University, Princeton University, Columbia University and the University of Pennsylvania.

Lilly files lawsuit against home town spa for selling repackaged Zepbound

Eli Lilly has sued Indianapolis-based spa Premier Weight Loss, claiming it buys tirzepatide autoinjector pens, cracks them open, breaking a sterile seal, and repackages them into lower unsterile doses, claiming the medicine is branded.

Rhythm eyes label expansion after Imcivree helps patients with brain damage-related obesity lose weight

Rhythm's Imcivree helped patients with obesity due to brain damage lose weight in a phase 3 study. With the trial win, the company is planning regulatory filings for what could be the first therapy approved in the rare disease population.

CDMO AmplifyBio closes doors amid tough market for early-stage cell and gene therapy development

On the heels of a recent cost-cutting drive that severed much of AmplifyBio’s R&D capacity, the Ohio-based contract manufacturing and research hybrid has hung up its hat for good. The company attributed the decision to a downturn in the market for early-stage development of cell and gene therapies, which it said stymied its ability to grow.
 
Fierce podcasts

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A closer look at pharma's top R&D budgets

This week on "The Top Line," we dive into our special report ranking the top pharma R&D budgets for 2024.
 

Resources

Unlocking Genomic Data: How NashBio is Advancing Innovation in Life Sciences

NashBio is transforming life sciences by making complex genomic and real-world data accessible for pharmaceutical R&D. Learn how their innovative Totem platform and groundbreaking Alliance for Genomic Discovery are accelerating research and improving outcomes.

eBook

Through a CRO's perspective: Innovative, Agile Solutions In Vaccine Efficacy Testing

Typical vaccine development timelines have averaged 10 years, but the time from the SARS-CoV-2 genetic sequence’s release to the submission of the first vaccine clinical trial data for regulatory review was a mere 314 days. In IQVIA Laboratories’ Vaccine eBook we focus on how contract research organizations (CROs) can best leverage strategic partnerships with sponsors to prepare for the next pandemic.
Whitepaper

Protect Your Trial Data: Endpoint, Imaging, and Safety Review

Avoid costly mistakes and ensure your clinical development program meets the highest standards by reading WCG’s whitepaper on Imaging Core Labs, Endpoint Adjudication Committees (EAC), and other safety reviews.
Research

Best Practice Customer-Facing Organization Study Report

We interviewed 15 biopharma leaders on the critical success factors for building a Best Practice customer-facing organization. This report shares what we learned.

 

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