Today's Rundown Featured Story | | | Sunday, March 31, 2019 CAR-T has seen a host of successes in blood cancers, but translating that into solid tumors has proven much more difficult. Now, early data out of the AACR cancer conference (and all the caveats that brings) may be offering some hope for that direction. |
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Top Stories Monday, April 1, 2019 California biotech Apexigen said during the annual American Association for Cancer Research meeting that a combination of its CD40-activating antibody with Bristol-Myers Squibb’s PD-1 inhibitor Opdivo and chemotherapy shrunk tumors in 20 out of 24 patients with pancreatic cancer. Monday, April 1, 2019 Novartis is picking up one clinical-stage and two preclinical NLRP3 antagonist programs in its acquisition of IFM Therapeutics' inflammation-centered subsidiary. Monday, April 1, 2019 Deloitte discusses how biotech companies are exploring alternative strategies to fund growth including IPOs, collaborative arrangements, and share-based payment arrangements. Monday, April 1, 2019 Patrick Soon-Shiong’s NantCell could lose its controlling stake in Precision Biologics through a legal settlement. The proposed settlement would effectively erase NantCell’s investment to clear up a case alleging Soon-Shiong improperly withdrew $47 million from Precision Biologics. Monday, April 1, 2019 TG Therapeutics’ PI3K delta inhibitor, umbralisib, put up encouraging phase 2b data in marginal zone lymphoma, shrinking tumors in more than half of the patients followed long enough to be evaluated. Of these patients, nearly one-fifth were in complete remission, that is, their cancer was undetectable after treatment. Monday, April 1, 2019 Cambridge Innovation Capital has raised £150 million ($196 million) to invest in startups emerging from a U.K. life sciences research hot spot. The financing will support existing portfolio companies such as Bicycle and Carrick Therapeutics and equip CIC to back additional businesses. Friday, March 29, 2019 With just one week left to go in his time as FDA commissioner, Scott Gottlieb described the serendipity of being able to lead the agency while it’s “writing the modern rules.” Monday, April 1, 2019 DNA damage response specialist Artios Pharma is the latest biotech to call a pharma executive into the startup fold as it poaches Ian Smith, M.D., as its new chief medical officer. Monday, April 1, 2019 SpringWorks Therapeutics raised $125 million in its series B to advance its two lead candidates, both of which are in development for noncancerous tumors: a gamma-secretase inhibitor for desmoid tumor and a MEK inhibitor for neurofibromatosis type 1. Sunday, March 31, 2019 AstraZeneca’s Tagrisso has taken the EGFR lung cancer market by storm, but some patients develop resistance to the therapy. Enter Chi-Med and its MET inhibitor, savolitinib. Resources Sponsored by: USDM Life Sciences The year’s biggest compliance and technology trends in life sciences. 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