Defying orders, NIH still pulling research grants: report

Today’s Big News

Mar 7, 2025

J&J fails to ace Ventura, stopping phase 3 depression program over 'insufficient efficacy'


Amgen and CytomX throw off masked T-cell engager, axing asset after assessing data, priorities


NIH still terminating research grants, defying federal orders: Boston Globe


Pfizer adds J&J, BMS vet James List to its executive roster as new chief internal medicine officer


Atea offloads a quarter of its workforce, gears up for phase 3 HCV trials


Chutes & Ladders—Sage CMO steps down amid pipeline struggles


Theriva puts GvHD drug on back burner to focus on oncolytic adenovirus


Arcturus confident of retaining BARDA funding for bird flu trial, despite Moderna uncertainty


Roche to house its CVRM research work at Harvard's new research campus

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J&J fails to ace Ventura, stopping phase 3 depression program over 'insufficient efficacy'

Johnson & Johnson has added to the opioid kappa blues. Months after Neumora reported a phase 3 flop, J&J has stopped development of its rival drug candidate aticaprant as an adjunctive treatment for major depressive disorder.
 

Top Stories

Amgen and CytomX throw off masked T-cell engager, axing asset after assessing data, priorities

Amgen and CytomX Therapeutics have kicked a phase 1 T-cell engager to the curb, axing the asset after assessing the clinical data and their pipeline priorities.

NIH still terminating research grants, defying federal orders: Boston Globe

In defiance of federal orders, the National Institutes of Health is still terminating grants to researchers across the country, The Boston Globe reports.

Pfizer adds J&J, BMS vet James List to its executive roster as new chief internal medicine officer

The newest executive to join the ranks at Pfizer is ten-year Johnson & Johnson vet James List, M.D., Ph.D. At Pfizer, he'll be responsible for leading the company’s pipeline of cardiovascular, metabolic, hematologic, and obesity medicines from early discovery to late development.

Atea offloads a quarter of its workforce, gears up for phase 3 HCV trials

Atea Pharmaceuticals has laid off a quarter of its workforce so far this year as the biotech prepares to launch a phase 3 trial of its hepatitis C cocktail.

Chutes & Ladders—Sage CMO steps down amid pipeline struggles

Sage Chief Medical Officer Laura Gault, M.D., Ph.D., is stepping down to pursue a new opportunity effective March 21, the latest change for a company that has had a recent string of clinical failures.

Theriva puts GvHD drug on back burner to focus on oncolytic adenovirus

Theriva Biologics is putting more of its eggs in the VCN-01 basket as it unveils a change up in its R&D focus.

Arcturus confident of retaining BARDA funding for bird flu trial, despite Moderna uncertainty

Arcturus believes it’s “highly unlikely” it will lose the government funding for its mRNA bird flu vaccine trial, despite rumors swirling that Moderna’s funding will be revoked.

Roche to house its CVRM research work at Harvard's new research campus

Roche and its Genentech subsidiary are planning to hitch up their cardiovascular, renal and metabolism R&D work and shift it over to a new center in Harvard’s Enterprise Research Campus.

A look at biotech's biggest money raisers of 2024

This week on "The Top Line," we dig into several of the biggest private funding rounds in biotech last year and discuss the shifting VC landscape.

In confirmation hearing, FDA nominee Martin Makary talks drug reviews, vaccines, ethics and more

If confirmed, Johns Hopkins surgeon Martin Makary, M.D., would take the reins at the FDA as the agency undergoes cost-cutting measures from the Trump administration.

Sycamore Partners to take Walgreens private in deal valued at $10B

The confirmation follows weeks of speculation and rumors that Sycamore was planning to take over Walgreens and take the company private.

Fierce Pharma Asia—Trump's investment policy; Pfizer's tariff mitigation plan; CMIC's stake sale

U.S. President Donald Trump has issued a memorandum directing federal agencies to restrict inbound and outbound investments related to China in several sectors, including biotech. Pfizer could shift overseas production to the U.S. if tariffs become a problem, CEO Albert Bourla said. Blackstone bought a 60% stake in Japanese CRO giant CMIC. And more.
 
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A look at biotech's biggest money raisers of 2024

This week on "The Top Line," we dig into several of the biggest private funding rounds in biotech last year and discuss the shifting VC landscape.
 

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