Atara halves staff after FDA hold

Today’s Big News

Mar 4, 2025

Acelyrin doubles down on Alumis merger after deciding Concentra’s surprise offer 'not superior'


VC firm Sofinnova brings in €1.2B over a year to fund up to 60 life sciences companies


Atara, reeling from FDA hold on Ebvallo, lays off half of workforce


Novartis hands over $55M upfront to license preclinical hives prospect from Japan's Kyorin


UPDATE: Biohaven's bipolar candidate fails to improve mania in pivotal trial


PepGen pauses UK arm of DMD trial that's already on hold in US


Fierce Biotech Fundraising Tracker '25: Garuda grabs $50M series A; Callio launches with $187M


Gene therapy prevents death, restores growth in mice and a calf with maple syrup urine disease


Pliant discontinues late-stage lung disease trial for lead asset after safety review

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Featured

Acelyrin doubles down on Alumis merger after deciding Concentra’s surprise offer 'not superior'

Acelyrin consulted with independent advisors and came to the conclusion that the unsolicited interest from Tang Capital Partners-owned Concentra was “not reasonably expected to result in a superior proposal to the planned merger with Alumis."
 

Top Stories

VC firm Sofinnova brings in €1.2B over a year to fund up to 60 life sciences companies

Up to 60 new life sciences companies are set to benefit from 1.2 billion euros ($1.68 billion) that Sofinnova Partners has raked in over the past year, the European venture capital firm has announced.

Atara, reeling from FDA hold on Ebvallo, lays off half of workforce

Atara Biotherapeutics is halving its head count as it navigates the fallout from the FDA’s move to halt on all of the allogeneic T-cell company’s attempts to launch fresh clinical trials.

Novartis hands over $55M upfront to license preclinical hives prospect from Japan's Kyorin

Deal-happy Novartis is further bolstering its preclinical pipeline and continuing its hunt for a Xolair successor, nailing down a licensing pact with Japanese biotech Kyorin potentially worth hundreds of millions of dollars.

UPDATE: Biohaven's bipolar candidate fails to improve mania in pivotal trial

Biohaven’s bipolar disorder candidate has failed to improve mania symptoms in a phase 2/3 trial.

PepGen pauses UK arm of DMD trial that's already on hold in US

While PepGen works to persuade the FDA to let it launch a phase 2 trial of its Duchenne muscular dystrophy therapy in the U.S., the biotech has decided to pause the U.K. arm of the study.

Fierce Biotech Fundraising Tracker '25: Garuda grabs $50M series A; Callio launches with $187M

The Fierce Biotech Fundraising Tracker records venture capital rounds of $50 million or more secured by biotechs.

Gene therapy prevents death, restores growth in mice and a calf with maple syrup urine disease

A one-time injection of a novel gene therapy was able to save mice and a newborn calf from succumbing to maple syrup urine disease, suggesting the treatment could one day be used to treat patients with the rare genetic disorder.

Pliant discontinues late-stage lung disease trial for lead asset after safety review

Pliant Therapeutics has discontinued a phase 2b/3 trial after recording at least a 7% higher rate of adverse events tied to idiopathic pulmonary fibrosis (IPF) in the treatment arms compared to placebo.

Pfizer could shift overseas production to US if Trump's pharma tariffs take hold, CEO says

Pfizer’s local manufacturing setup is already well positioned in the U.S., and the New York-based drugmaker could bring additional resources into the country if pharma import tariffs proposed by President Donald Trump take effect, the company's CEO, Albert Bourla, Ph.D., said Monday.

Paragonix's donor kidney perfusion system completes commercial flight

The KidneyVault is more than a simple ice chest. It pumps a cooled, specialized solution through the organ to help preserve it on the way to surgery.

AstraZeneca, Daiichi unblind Enhertu study early as star ADC helps stomach cancer patients live longer

AstraZeneca and Daiichi Sankyo's Enhertu has become the first HER2-directed drug to mount a patient survival benefit in a randomized clinical trial in second-line metastatic stomach cancer, the partners said on Monday.
 
Fierce podcasts

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Research reveals ‘ticking DNA clock’ behind Huntington’s disease

This week on "The Top Line," we hear from Steven McCarroll, Ph.D., whose research team at the Broad Institute of MIT and Harvard recently uncovered new insights into the cause of Huntington's disease.
 

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